It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the
first 80 years, very little progress was made in understanding the mechanisms that caused …

Genetic studies of autosomal dominant Alzheimer's disease (AD) revealed that β-amyloid is
central to disease pathogenesis. However, amyloid-targeted therapies have generally failed …

Amyloidopathies cause neurodegeneration in a substantial portion of the elderly population.
Improvements in long term health care have made elderly individuals a large and growing …

Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …

Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a
combination of multiple factors. Among the many pathological pathways, synaptic …

Introduction: The molecular pathogenesis of Alzheimer's disease (AD) includes a variety of
risk factors, extracellular deposition of β-amyloid, accumulation of intracellular neurofibrillary …

Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …

Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …

Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …