Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3

IA Khatri, R Wang, JF Forstner - Biochemical Journal, 2004 - portlandpress.com
Rat intestinal mucin Muc3 (rMuc3), like its human homologue (MUC3) and several other
membrane mucins, contains a C-terminally located SEA (sea urchin sperm protein …

C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components

R Wang, IA Khatri, JF Forstner - Biochemical Journal, 2002 - portlandpress.com
Although human MUC3 and rodent Muc3 are both membrane-associated intestinal mucins,
the present study has explored the possibility that rodent Muc3 might exist in soluble as well …

Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3

Y Li, Z Peng, Y He, W Chen, X Bian, D Fang… - Molecular and cellular …, 2008 - Springer
In previous works, we showed by transient expression studies in COS-1 cells that the C-
terminal domain of rat intestinal membrane mucin (rMuc3) that was cloned in the pSecTag2 …

C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components

W Rongquan, IA KHATRI, JF FORSTNER - Biochemical Journal, 2002 - cir.nii.ac.jp
抄録< jats: p> Although human MUC3 and rodent Muc3 are both membrane-associated
intestinal mucins, the present study has explored the possibility that rodent Muc3 might exist …

SEA (sea-urchin sperm protein, enterokinase and agrin)-module cleavage, association of fragments and membrane targeting of rat intestinal mucin Muc3

IA Khatri, R Wang, JF Forstner - Biochemical Journal, 2003 - portlandpress.com
In a previous study we showed, by transient expression studies in COS-1 cells, that the C-
terminal domain of rat intestinal membrane mucin Muc3 was cleaved between glycine and …

Gastrointestinal expression and partial cDNA cloning of murine Muc2

BJW Van Klinken, AWC Einerhand… - American Journal …, 1999 - journals.physiology.org
To help us investigate the role of mucin in the protection of the colonic epithelium in the
mouse, we aimed to identify the murine colonic mucin (MCM) and its encoding gene. We …

[HTML][HTML] The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment

K Godl, MEV Johansson, ME Lidell… - Journal of Biological …, 2002 - ASBMB
The N terminus of the human MUC2 mucin (amino acids 1–1397) has been expressed as a
recombinant tagged protein in Chinese hamster ovary cells. The intracellular form was found …

[HTML][HTML] The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs

IA Khatri, GG Forstner, JF Forstner - Biochimica et Biophysica Acta (BBA) …, 1997 - Elsevier
A 3′ RACE technique was used to establish the nucleotide sequence encoding the C-
terminal 379 amino acids of rat intestinal Muc3. Unlike the C-terminus of Muc2 and many …

Genomic organization and structure of the 3′ region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin

SC Crawley, JR Gum Jr, JW Hicks, WS Pratt… - Biochemical and …, 1999 - Elsevier
The MUC3 gene encodes a large, glycosylated mucin produced by intestinal epithelial cells
to form a protective barrier against the external environment. Recently published cDNA …

[HTML][HTML] Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells

SJ Williams, DH Wreschner, M Tran, HJ Eyre… - Journal of Biological …, 2001 - ASBMB
Transmembrane mucins are glycoproteins involved in barrier function in epithelial tissues.
To identify novel transmembrane mucin genes, we performed a tblastn search of the …