The last half century of cancer research has seen an explosion in our understanding of the
complex interplay between cancer cells and host-derived factors critical for cancer …

The association of malignancy and thrombophilia is bidirectional, as evidenced by four
decades of studies in animal models showing that hemostatic system components support …

Coagulation proteases and the generation of thrombin are increased in tumors. In addition,
chemotherapeutic agents commonly used to treat malignant cancers can exacerbate cancer …

Thrombin, a pleiotropic enzyme involved in coagulation, plays a crucial role in both
procoagulant and anticoagulant pathways. Thrombin converts fibrinogen into fibrin, initiates …

Significant data have accumulated demonstrating a reciprocal relationship between cancer
and the hemostatic system whereby cancer promotes life‐threatening hemostatic system …

Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link
between inflammation and cancer. Proinflammatory signaling functions of thrombin are …

Advances in understanding the molecular mechanisms of tumor progression have achieved
impressive progress in the treatment of cancer and so-called immune checkpoint inhibitors …

Pathological activation of the coagulation system occurs with virtually all forms of cancer,
particularly epithelial malignancies. Accordingly, thrombosis is one of the most common …

Coagulation is a highly conserved process occurring after an injury to a blood vessel and
resulting in hemostasis. In the thrombus microenvironment, finely orchestrated events …

Genetics-based studies have established the critical importance of tumor cell-associated
tissue factor, circulating and endothelial cell-associated regulators of thrombin function and …