Evidence for multi‐site closure of the neural tube in humans

MI Van Allen, DK Kalousek, GF Chernoff… - American journal of …, 1993 - Wiley Online Library
Four separate initiation sites for neural tube (NT) fusion have been demonstrated recently in
mice and other experimental animals. We evaluated the question of whether the mult‐site …

Sex, neural tube defects, and multisite closure of the human neural tube

MJ Seller - American journal of medical genetics, 1995 - Wiley Online Library
While neural tube defects (NTD) overall have a female sex bias, this does not apply to all
sites along the neuraxis. The findings regarding sex and NTD in a series of midtrimester …

Etiologic heterogeneity of neural tube defects. II. Clues from family studies.

MJ Khoury, JD Erickson, LM James - American Journal of Human …, 1982 - ncbi.nlm.nih.gov
We previously reported that among neural tube defects (NTDs) with no known causes the
ones that occur alone (singles) have different epidemiologic characteristics from those that …

Genetics and development of neural tube defects

AJ Copp, NDE Greene - The Journal of Pathology: A Journal of …, 2010 - Wiley Online Library
Congenital defects of neural tube closure (neural tube defects; NTDs) are among the
commonest and most severe disorders of the fetus and newborn. Disturbance of any of the …

Epidemiology of neural tube defects

L Frey, WA Hauser - Epilepsia, 2003 - Wiley Online Library
Neural tube defects (NTDs)—malformations secondary to abnormal neural tube closure
between the third and fourth weeks of gestational age—have a complex and imperfectly …

Insights into the etiology of mammalian neural tube closure defects from developmental, genetic and evolutionary studies

DM Juriloff, MJ Harris - Journal of developmental biology, 2018 - mdpi.com
The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis,
originate from a failure of the embryonic neural tube to close. Human NTD are relatively …

Multiple sites of anterior neural tube closure in humans: evidence from anterior neural tube defects (anencephaly)

JA Golden, GF Chernoff - Pediatrics, 1995 - publications.aap.org
Objective. Anterior neural tube closure in humans is thought to occur via a continuous
process, culminating in the closure of the anterior neuropore. Recent studies have …

Epidemiologic characteristics of phenotypically distinct neural tube defects among 0.7 million California births, 1983–1987

GM Shaw, NG Jensvold, CR Wasserman… - Teratology, 1994 - Wiley Online Library
Isolated neural tube defects (NTDs) appear to have different risk factors compared to
nonisolated NTDs. To extend those observations, we explored routinely collected child and …

Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects

MJ Harris, DM Juriloff - Birth Defects Research Part A: Clinical …, 2007 - Wiley Online Library
BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

Epidemiology of neural tube defects

LE Mitchell - American journal of medical genetics Part C …, 2005 - Wiley Online Library
The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …