The influence of the granulocyte/monocyte apheresis (GMCAP) on cell populations
participating in mechanisms of tolerance, eg dendritic cells (DCs), is still not very clear. In a …

Abstract Background and Aim: In human blood, two main subsets of antigen‐presenting‐
cells (APCs) have been described: plasmocytoid dendritic cells (pDC) and myeloid dendritic …

The aim of this study was to elucidate the molecular mechanisms responsible for the
therapeutic effects of granulocyte and monocyte adsorption apheresis (GMA). We …

Background: The number of ulcerative colitis (UC) patients is increasing in Japan and other
countries. Selective depletion of myeloid lineage leucocytes by adsorptive granulocyte and …

BACKGROUND AND OBJECTIVE: Elevated/activated myeloid leucocytes, like the CD14 (+)
CD16 (+) monocytes are sources of TNF-α, and therefore, selective depletion of these cells …

Background/Aims: In patients with active ulcerative colitis (UC), pharmacologics, although
initially effective in most patients, are associated with refractoriness, loss of response or …

Our aim was to understand the mechanism of immunological changes associated with the
use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for …

Background & Aims: Active ulcerative colitis (UC) is characterized by infiltration of activated
granulocytes and monocytes/macrophages (GM) within the large bowel mucosa. GM are …

Despite controversy regarding the use of granulocyte/monocyte adsorption (GMA) in
inflammatory bowel disease, some studies have shown favorable outcomes when it is used …

BACKGROUND AND AIM: Several uncontrolled studies have reported on the efficacy of
adsorptive depletion of peripheral blood granulocytes and monocytes/macrophages (GMA) …