EBV (Epstein–Barr virus) alternates between latency and lytic replication. During latency, the
viral genome is largely silenced by host-driven methylation of CpG motifs and in the switch …

DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus
(EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely …

Abstract In infected cells, Epstein–Barr virus (EBV) alternates between latency and lytic
replication. The viral bZIP transcription factor ZEBRA (Zta, BZLF1) regulates this cycle by …

Epstein-Barr virus (EBV) encoded transcription factor Zta (BZLF1, ZEBRA, EB1) is the
prototype of a class of transcription factor (including C/EBPalpha) that interact with CpG …

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with various
malignancies, including Burkitt's lymphoma and nasopharyngeal carcinoma. Like all …

DNA methylation promotes gene silencing, yet the Epstein-Barr virus immediate-early
protein, BZLF1 (Z), converts the virus from the latent to the lytic form of infection even when …

ABSTRACT The Epstein-Barr virus (EBV) genome is highly methylated in latently infected
cells. We recently reported that the EBV immediate-early (IE) protein BZLF1 (Z) preferentially …

Activation of the host gene egr1 is essential for the lytic replication of Epstein–Barr virus
(EBV). egr1 is activated by Zta (BZLF1, ZEBRA). Zta interacts directly with DNA through a …

The switch between latent and lytic Epstein-Barr virus (EBV) infection is mediated by the
viral immediate-early (IE) protein, BZLF1 (Z). Z, a homologue of c-jun that binds to AP1-like …

Epigenetic mechanisms are essential for the regulation of all genes in mammalian cells but
transcriptional repression including DNA methylation are also major epigenetic mechanisms …