Endothelial dysfunction is a key early step in atherosclerosis. 25-Hydroxycholesterol (25-
OHC) is found in atherosclerotic lesions. However, whether 25-OHC promotes …

The atherogenic potential of oxidized low-density lipoproteins (oxLDL) has been correlated
to their 7β-hydroxycholesterol (7βOHC) content; oxLDLs have a dual effect on endothelial …

Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism,
including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant …

Among components of oxidized low density lipoproteins, cholesterol derivatives oxidized in
position 7 inhibit endothelium‐dependent arterial relaxation by decreasing the release of the …

Objective and design The damage of barrtier tissues, such as the vascular endothelium and
intestinal epithelium, may lead to disturbances of local immune homeostasis. The aim of the …

Statins can protect endothelial activation independent from their lipid-lowering effects. To
gain more insight in mechanisms via which HMG-CoA inhibition may attenuate endothelial …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Relatively brief periods (days) of hypercholesterolemia can exert profound effects on
endothelium-dependent functions of the microcirculation, including dilation of arterioles, fluid …

Objective—Oxysterols such as 7-ketocholesterol (7-KC) are important mediators of cell
death in atherosclerosis. Therefore, in vitro studies of human smooth muscle cell (SMC) …

Oxidized cholesterols belong to a subgroup of oxLDLs which play major roles in
atherosclerosis. In order to investigate the contribution of oxysterols from oxLDLs in …