Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ–induced inflammatory responses and LXR-dependent gene expression

M Pascual-Garcia, L Rué, T León, J Julve… - The Journal of …, 2013 - journals.aai.org
Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of
inflammation. In this study we have explored the impact of LXR activation on the …

[HTML][HTML] Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

A Noelia, A Castrillo - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor family of
transcription factors that play essential roles in the transcriptional control of lipid metabolism …

Biological roles of liver X receptors in immune cells

M Pascual-García, AF Valledor - Archivum immunologiae et therapiae …, 2012 - Springer
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated
by specific oxysterols. LXRs heterodimerize with retinoid X receptors to regulate positively …

Liver X receptors link lipid metabolism and inflammation

IG Schulman - FEBS letters, 2017 - Wiley Online Library
The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to …

Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses

MA Birrell, MC Catley, E Hardaker, S Wong… - Journal of Biological …, 2007 - ASBMB
The liver X receptors (LXRα/β) are part of the nuclear receptor family and are believed to
regulate cholesterol and lipid homeostasis. It has also been suggested that LXR agonists …

Liver X receptor activation promotes differentiation of regulatory T cells

M Herold, J Breuer, S Hucke, P Knolle, N Schwab… - PloS one, 2017 - journals.plos.org
The nuclear receptor Liver X Receptor (LXR) is a ligand-activated transcription factor that
has been implicated in control of chronic inflammation by downregulating pro-inflammatory …

Identification of interferon-γ as a new molecular target of liver X receptor

Q Wang, X Ma, Y Chen, L Zhang, M Jiang… - Biochemical …, 2014 - portlandpress.com
LXR (liver X receptor) is a ligand-activated transcription factor and plays an important role in
regulation of lipid homoeostasis and inflammation. Several studies indicate that LXR inhibits …

The roles of liver X receptor α in inflammation and inflammation‐associated diseases

L Zhao, W Lei, C Deng, Z Wu, M Sun… - Journal of cellular …, 2021 - Wiley Online Library
Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the
nuclear receptor family of transcription factors and plays essential roles in the transcriptional …

Liver x receptors in atherosclerosis and inflammation

SS Im, TF Osborne - Circulation research, 2011 - Am Heart Assoc
Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key
regulators of lipid metabolism and transport but also suppress inflammatory signaling in …

Common and differential transcriptional actions of nuclear receptors liver X receptors α and β in macrophages

A Ramón-Vázquez, JV de la Rosa… - … and cellular biology, 2019 - Taylor & Francis
The liver X receptors α and β (LXR α and LXR β) are oxysterol-activated transcription factors
that coordinately regulate gene expression that is important for cholesterol and fatty acid …