DNA methylation and demethylation: a pathway to gametogenesis and development
W Dean - Molecular Reproduction and Development, 2014 - Wiley Online Library
The generation of gametes falls between two reprogramming phases. These phases are
characterised by profound periods of transcriptional activity, which define and reinforce …
characterised by profound periods of transcriptional activity, which define and reinforce …
Active demethylation of the paternal genome in the mouse zygote
J Oswald, S Engemann, N Lane, W Mayer, A Olek… - Current Biology, 2000 - cell.com
DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …
mammals [1]. Mammalian development is accompanied by two major waves of genome …
DNA methylation in early development
TM Geiman, K Muegge - Molecular Reproduction and …, 2010 - Wiley Online Library
Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …
proceeding to a fully functioning adult animal occurs through an intricate program of …
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers
In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …
[PDF][PDF] Epigenetic patterning in male germ cells: importance of DNA methylation to progeny outcome
S La Salle, JM Trasler, C De Jonge… - The sperm cell …, 2006 - academia.edu
Epigenetics refers to non-sequence based mechanisms that control gene expression and
has been described as the next 'frontier'in genetics. This chapter focuses on DNA …
has been described as the next 'frontier'in genetics. This chapter focuses on DNA …
Active DNA demethylation in mammalian preimplantation embryos: new insights and new perspectives
JY Ma, XW Liang, H Schatten… - MHR: Basic science of …, 2012 - academic.oup.com
DNA methylation and demethylation are crucial for modulating gene expression and
regulating cell differentiation. Functions and mechanisms of DNA methylation/demethylation …
regulating cell differentiation. Functions and mechanisms of DNA methylation/demethylation …
The role of DNA methylation in mammalian development
CE Senner - Reproductive biomedicine online, 2011 - Elsevier
DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …
Origin and roles of genomic methylation patterns in male germ cells
JM Trasler - Seminars in cell & developmental biology, 1998 - Elsevier
The epigenetic modification of DNA by methylation at cytosine residues is initiated in the
germ line and is required for normal embryonic development in mammals. Marked …
germ line and is required for normal embryonic development in mammals. Marked …
Pathways of DNA demethylation
W Dean - DNA Methyltransferases-Role and Function, 2016 - Springer
The regulation of the genome relies on the epigenome to instruct, define and restrict the
activities of growth and development. Among the cohort of epigenetic instructions, DNA …
activities of growth and development. Among the cohort of epigenetic instructions, DNA …
Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development
T Haaf - DNA methylation: development, genetic disease and …, 2006 - Springer
In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …
parent-specific epigenetic reprogramming during preimplantation development. The …
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