[HTML][HTML] Soluble ACE2 as a potential therapy for COVID-19

S Krishnamurthy, RF Lockey… - American Journal of …, 2021 - journals.physiology.org
Soluble angiotensin-converting enzyme 2 (sACE2) could be a therapeutic option to treat
coronavirus disease 2019 (COVID-19) infection. Severe acute respiratory syndrome …

ACE2 Shedding and the Role in COVID-19

J Wang, H Zhao, Y An - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Human recombinant soluble ACE2 (hrsACE2) shows promise for treating severe COVID19

TM Abd El-Aziz, A Al-Sabi, JD Stockand - Signal Transduction and …, 2020 - nature.com
A recent study by Zoufaly et al. published in The Lancet Respiratory Medicine describes
encouraging data from the first severe COVID-19 patient successfully treated with human …

ACE2 as a therapeutic target for COVID-19; its role in infectious processes and regulation by modulators of the RAAS system

V Michaud, M Deodhar, M Arwood… - Journal of Clinical …, 2020 - mdpi.com
Angiotensin converting enzyme 2 (ACE2) is the recognized host cell receptor responsible for
mediating infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Targeting ACE2 for COVID-19 therapy: opportunities and challenges

H Jia, E Neptune, H Cui - American journal of respiratory cell and …, 2021 - atsjournals.org
The coronavirus disease (COVID-19) pandemic is sweeping the globe. Even with a number
of effective vaccines being approved and available to the public, new cases and escalating …

[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator

J Bian, Z Li - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 …

Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications

AM Davidson, J Wysocki, D Batlle - Hypertension, 2020 - Am Heart Assoc
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 originated from Wuhan,
China, in December 2019 and rapidly spread to other areas worldwide. Since then …

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

M Oz, DE Lorke, N Kabbani - Pharmacology & therapeutics, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2

M Gheblawi, K Wang, A Viveiros, Q Nguyen… - Circulation …, 2020 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …