This article is part of a Special Issue “SBN 2014”. Sex hormones are physiological factors
that promote neurogenesis during embryonic and fetal development. During childhood and …

Estradiol, the most potent and prevalent member of the estrogen class of steroid hormones
and is expressed in both sexes. Functioning as a neuroactive steroid, it plays a crucial role …

INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

Several metabolic and behavioral adaptations that emerge during pregnancy remain
present after weaning. Thus, reproductive experience causes long-lasting metabolic …

Background Recent advances in neuroscience tools for single-cell molecular profiling of
brain neurons have revealed an enormous spectrum of neuronal subpopulations within the …

This review lays out the evidence for the role of E2 in homeostatic and hedonic feeding
across several species. While significant effort has been expended on homeostatic feeding …

Many studies have shown the importance of an adequate nutritional environment during
development to optimally establish the neurohormonal circuits that regulate feeding …

Circulating estradiol exerts a profound influence on the activity of the gonadotropin-
releasing hormone (GnRH) neuronal network controlling fertility. Using genetic strategies …

Energy homeostasis depends on the balance between the amount of food consumed
(energy intake) and the amount of calories used (energy expenditure). The precise …

Metabolic hormones, such as leptin, alter the input organization of hypothalamic circuits,,,
resulting in increased pro-opiomelanocortin (POMC) tone, followed by decreased food …