Publisher Summary Ca 2+ serves as a versatile extracellular first messenger, in many
instances acting via the Ca 2+-sensing receptor (CaR) that controls numerous physiological …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The recent cloning of an extracellular calcium (Ca2+ o)-sensing receptor (CaR) from
parathyroid, kidney and other cell types has clarified the mechanisms through which Ca2+ o …

Calcium ions are of vital importance for the human body. Both within the outside of the cell,
calcium (Ca 2+) plays key roles in numerous crucial physiological processes. Intracellular …

The system governing extracellular calcium (Ca2+ o) homeostasis maintains near constancy
of Ca2+ o so as to ensure continual availability of calcium ions for their numerous …

Calcium (Ca2+) has long been recognized as a physiologically indispensable ion owing to
its numerous intra-and extracellular roles. More recently, it has become apparent that …

Bone is the major sink and store for calcium and it fulfils essential roles in the maintenance
of extracellular free ionised calcium concentration ([Ca2+] e) within its homeostatic range …

Abstract The extracellular calcium (Ca 2+ _o)-sensing receptor (CaR) enables the
parathyroid glands and other CaR-expressing cells to sense alterations in the level of Ca 2+ …

This chapter describes the properties and functions of the Ca2+ o‐sensing receptor (CaSR),
a G‐protein coupled receptor (GPCR) that plays a central role in Ca2+ o homeostasis by …

The ability of parathyroid cells to recognize and respond to (ie," sense") small changes in the
extracellular Ca2+ concentration (Ca2+ o) plays a crucial role in mineral ion homeostasis …