We present a novel, rare but recurrent variant three way translocation of t (8; 21), t (8; 16;
21)(q22; q24; q22), as a primary cytogenetic abnormality, resulting in AML1/ETO fusion …

Acute myeloid leukemia associated with translocation t (8; 21) and the underlying AML1-
ETO gene fusion is considered as a distinct type of leukemia with characteristic morphologic …

Variant forms of the classic translocation t (8; 21) are uncommon and account approximately
3% of all t (8; 21)(q22; q22) in acute myeloid leukemia (AML) patients. These forms involve …

Abstract The translocation (8; 21)(q22; q22) is associated with acute myeloblastic leukemia
(AML) with M2 subtype. The accurate detection of this chromosomal rearrangement is vital …

Cytogenetic abnormalities play an important role in diagnosis, classification and prognosis
in acute myeloid leukemia (AML). Nevertheless, several chromosome abnormalities have …

The complex variants of t (8; 21) involving chromosomes 8 and 21 as well as a variable
chromosome account for 1.1∼ 5% of acute myeloid leukemia (AML) patients. This paper …

We report a male patient with acute myelogenous leukemia (AML; French–American–British
M2) associated with AML1-ETO. Cytogenetic studies showed a complex karyotype including …

Acute myeloid leukemia (AML) with the t (8; 21)(q22; q22) creating the AML1-ETO fusion
gene is a distinct type of AML generally associated with a favorable prognosis. The …

We report the results of cytogenetic, fluorescence in situ hybridization (FISH) and molecular
analyses in a 15-year-old boy diagnosed with acute myeloid leukemia subtype M2 (AML …

Background: Acute myeloid leukemia (AML) is a heterogeneous group of malignant
neoplasm of hematopoietic disorders characterized by an abnormal proliferation of myeloid …