Type 1 diabetes (T1D) is an autoimmune disease for which there is no cure. The pancreatic
beta cells are the source of insulin that keeps blood glucose normal. When susceptible …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting 3 million individuals in
the US The pathogenesis of T1DM is driven by immune-mediated destruction of pancreatic β …

Abstract Type 1 diabetes (T1D) is an autoimmune disease resulting in the destruction of the
insulin-producing pancreatic beta cells. Disease progression occurs along a trajectory from …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Type 1 diabetes mellitus (T1D) is an autoimmune illness that affects millions of patients
worldwide. The main characteristic of this disease is the destruction of pancreatic insulin …

In type 1 diabetes (T1D) the immune system attacks insulin‐producing pancreatic β‐cells.
Unfortunately, our ability to curb this pathogenic autoimmune response in a disease‐and …

It is now clear that type 1A (immune-mediated) diabetes develops in genetically susceptible
individuals where, prior to the onset of overt hyperglycaemia, there is usually a long …

Type 1 diabetes (T1D) results from autoimmune destruction of the pancreatic β-cells. Current
T1D therapies are exclusively focused on regulating glycemia rather than the underlying …

T cell-directed immunosuppression only transiently delays the loss of β cell function in
recent-onset type 1 diabetes. We argue here that the underlying disease process is carried …

Summary Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features− precise …