Osteoarthritis (OA) is the most common musculoskeletal disease, affecting nearly 25% of the
world population (WHO reports), leading to pain and disability. There are as yet no clinically …

Background The prevalence of osteoarthritis (OA) increases with obesity, with up to two
thirds of the elderly obese population affected by OA of the knee. The metabolic syndrome …

Obesity is one of the main risk factors for osteoarthritis (OA). For many years the association
of obesity and OA has been simply attributed to the effects of overload on weight-bearing …

Abstract Purpose of Review Metabolic syndrome (MetS), also called the 'deadly
quartet'comprising obesity, diabetes, dyslipidemia, and hypertension, has been ascertained …

OA is a complex disease involving mechanical, metabolic and inflammatory contributions to
its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its …

Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Projections by the Centers for Disease Control (CDC) suggest that if current trends continue,
by 2030, 20% of the US population will be over age 65, and 86% or the population will be …

Metabolic syndrome-associated osteoarthritis (Met-OA) is a clinical phenotype defined by
the role of obesity and metabolic syndrome as risk factors and by chronic low-grade …

Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …