Background Pain is a significant public health concern, and current pharmacological
treatments have problematic side effects and limited effectiveness. N‐methyl‐d‐aspartate …

The N-methyl-d-aspartic acid (NMDA) receptor antagonist d, l-2-amino-5-
phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide …

The aim of this study was to investigate role of the N-Methyl-D-Aspartate (NMDA) receptors
in the decrease of morphine analgesia in mice after nociceptive sensitization. We used a hot …

The effect of subcutaneous injection of glutamate on the mechanical sensitivity of rat facial
cutaneous mechanoreceptors was examined. Individual facial mechanoreceptors were …

The d-enantiomer of the opioid methadone is a weak opioid with low micromolar affinity to
the N-methyl-d-aspartate (NMDA) receptor. We have investigated the antinociception and in …

We have previously documented that peripheral N-methyl-d-aspartate (NMDA) receptor
mechanisms are involved in nociceptive reflex increases in jaw muscle activity to injection of …

Key points• Activation of N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) is a crucial
mechanism underlying the development and maintenance of pain.• Little is known about the …

Aim: To determine if glutamate injected into the healthy temporomandibular joint (TMJ)
evokes pain through peripheral N-methyl-D-aspartate (NMDA) receptors and if such pain is …

Previous studies showed that triptans and other 5-HT1B/1D-receptor agonists attenuate
hyper-responsiveness to mechanical stimulation of the face in a rat model of trigeminal …

The role of the N-methyl-d-aspartate receptor (NMDAr) as a contributor to maladaptive
neuroplasticity underlying the maintenance of chronic pain is well established. Agmatine, an …