Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion

J Han, M Tang, Y Yang, W Sun, Z Yue, Y Zhang… - International Journal of …, 2023 - Elsevier
Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method

ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation

A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying─Comparison of In Vitro and In Vivo Performance

E Trenkenschuh, SM Blattner, D Hirsh… - Molecular …, 2024 - ACS Publications
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable
from an economic and ecological perspective but also limited to thermostable active …

The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform

Y Tian, E Jacobs, DS Jones, CP McCoy, H Wu… - International journal of …, 2020 - Elsevier
Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the
bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors …

Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development

A Butreddy, S Bandari, MA Repka - European Journal of Pharmaceutical …, 2021 - Elsevier
An industrially feasible approach to overcome the solubility and bioavailability limitations of
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …

Continuous formulation approaches of amorphous solid dispersions: significance of powder flow properties and feeding performance

E Szabó, B Démuth, DL Galata, P Vass, E Hirsch… - Pharmaceutics, 2019 - mdpi.com
Preparation and formulation of amorphous solid dispersions (ASDs) are becoming more and
more popular in the pharmaceutical field because the dissolution of poorly water-soluble …

Manufacturing strategies to develop amorphous solid dispersions: An overview

N Mendonsa, B Almutairy, VR Kallakunta… - Journal of Drug Delivery …, 2020 - Elsevier
Since the past several decades, poor water solubility of existing and new drugs in the
pipeline have remained a challenging issue for the pharmaceutical industry. Literature …

Processing impact on in vitro and in vivo performance of solid dispersions—a comparison between hot-melt extrusion and spray drying

Y Li, AKP Mann, D Zhang, Z Yang - Pharmaceutics, 2021 - mdpi.com
Presently, a large number of drug molecules in development are BCS class II or IV
compounds with poor aqueous solubility. Various novel solubilization techniques have been …