Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion
J Han, M Tang, Y Yang, W Sun, Z Yue, Y Zhang… - International Journal of …, 2023 - Elsevier
Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …
in vitro and in vivo performances of poorly water-soluble drugs, such as …
Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …
invasive, easy to administer, and easy to store. However, drug formulation for oral …
A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation
A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …
recent years, with the potential to improve the apparent solubility and, hence, the oral …
[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …
Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying─Comparison of In Vitro and In Vivo Performance
E Trenkenschuh, SM Blattner, D Hirsh… - Molecular …, 2024 - ACS Publications
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable
from an economic and ecological perspective but also limited to thermostable active …
from an economic and ecological perspective but also limited to thermostable active …
The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform
Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the
bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors …
bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors …
Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development
An industrially feasible approach to overcome the solubility and bioavailability limitations of
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …
Continuous formulation approaches of amorphous solid dispersions: significance of powder flow properties and feeding performance
Preparation and formulation of amorphous solid dispersions (ASDs) are becoming more and
more popular in the pharmaceutical field because the dissolution of poorly water-soluble …
more popular in the pharmaceutical field because the dissolution of poorly water-soluble …
Manufacturing strategies to develop amorphous solid dispersions: An overview
Since the past several decades, poor water solubility of existing and new drugs in the
pipeline have remained a challenging issue for the pharmaceutical industry. Literature …
pipeline have remained a challenging issue for the pharmaceutical industry. Literature …
Processing impact on in vitro and in vivo performance of solid dispersions—a comparison between hot-melt extrusion and spray drying
Y Li, AKP Mann, D Zhang, Z Yang - Pharmaceutics, 2021 - mdpi.com
Presently, a large number of drug molecules in development are BCS class II or IV
compounds with poor aqueous solubility. Various novel solubilization techniques have been …
compounds with poor aqueous solubility. Various novel solubilization techniques have been …
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