Characterization and performance assessment of solid dispersions prepared by hot melt extrusion and spray drying process
AM Agrawal, MS Dudhedia, AD Patel… - International journal of …, 2013 - Elsevier
The present study investigated effect of manufacturing methods such as hot melt extrusion
(HME) and spray drying (SD) on physicochemical properties, manufacturability, physical …
(HME) and spray drying (SD) on physicochemical properties, manufacturability, physical …
Characterizing and exploring the differences in dissolution and stability between crystalline solid dispersion and amorphous solid dispersion
X Wang, L Zhang, D Ma, X Tang, Y Zhang, T Yin… - Aaps …, 2020 - Springer
Solid dispersion is one of the most effective ways to improve the dissolution of insoluble
drugs. When the carrier can highly disperse the drug, it will increase the wettability of the …
drugs. When the carrier can highly disperse the drug, it will increase the wettability of the …
The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets
Amorphous solid dispersion (ASD) is an effective approach for enhancing the solubility,
dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable …
dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable …
Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high …
W Fan, W Zhu, X Zhang, Y Xu, L Di - RSC advances, 2019 - pubs.rsc.org
The aim of the study was to develop an amorphous solid dispersion of a poorly water-
soluble drug with high melting point by ball milling and hot melt extrusion as a co-processing …
soluble drug with high melting point by ball milling and hot melt extrusion as a co-processing …
Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
Evaluation of different screening methods to understand the dissolution behaviors of amorphous solid dispersions
TWY Lee, NA Boersen, G Yang… - Drug Development and …, 2014 - Taylor & Francis
Objective: The objectives of the current study were to understand the dissolution behaviors
of amorphous solid dispersions (ASD) using different screening methods and their …
of amorphous solid dispersions (ASD) using different screening methods and their …
Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design
JA Lugtu-Pe, A Ghaffari, K Chen, A Kane… - European Journal of …, 2018 - Elsevier
The amorphous solid dispersion (ASD) technique has been employed to formulate poorly-
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at …
Amorphous solid dispersions are a promising option for managing compounds with poor
aqueous solubility. However, for compounds with high melting points, thermal stability …
aqueous solubility. However, for compounds with high melting points, thermal stability …
The utilization of drug–polymer interactions for improving the chemical stability of hot-melt extruded solid dispersions
Objective Interactions between drugs and polymers were utilized to lower the processing
temperature of hot-melt extrusion (HME), and thus minimize the thermal degradation of heat …
temperature of hot-melt extrusion (HME), and thus minimize the thermal degradation of heat …
[HTML][HTML] Overcoming drug impurity challenges in amorphous solid dispersion with rational development of biorelevant dissolution-permeation method
T Huzjak, O Jakasanovski, K Berginc, V Puž… - European Journal of …, 2024 - Elsevier
Hot-melt extrusion is often used to prepare amorphous solid dispersion to overcome low
drug solubility and enhance bio-performance of the formulation. Due to the uniqueness of …
drug solubility and enhance bio-performance of the formulation. Due to the uniqueness of …