Improving oral bioavailability of drugs those given as solid dosage forms remains a
challenge for the formulation scientists due to solubility problems. The dissolution rate could …

There are many methods to increase solubility of a substance. These include, inter alia,
preparation of solid dispersions, ie eutectic mixtures, solid solutions, glassy solutions and …

Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

Specific mechanical energy (SME) is a frequently overlooked but essential parameter of hot-
melt extrusion (HME). It can determine whether an amorphous solid dispersion (ASD) can …

The formulation development of amorphous solid dispersions (ASDs) towards a patient-
friendly oral solid dosage form is proving to be still challenging. To increase patient's …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Freeze drying is known to be able to produce an amorphous product, but this approach has
been mostly used with water-based media. With APIs which are virtually water insoluble, a …

Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly
soluble pharmaceutical compounds in development. These systems consist of an …

Formulation of active pharmaceutical ingredients (API) in high-energy amorphous forms is a
common strategy to enhance solubility, dissolution rate and, consequently, oral …

Purpose The purpose of this work is to evaluate the interrelationship of microstructure,
properties, and dissolution performance for amorphous solid dispersions (ASDs) prepared …