Molecular mechanisms in nickel carcinogenesis: modeling Ni (II) binding site in histone H4.
MA Zoroddu, L Schinocca… - Environmental …, 2002 - ehp.niehs.nih.gov
Ni (II) compounds are well known as human carcinogens, though the molecular events
which are responsible for this are not yet fully understood. It has been proposed that the …
which are responsible for this are not yet fully understood. It has been proposed that the …
Molecular models in nickel carcinogenesis
W Bal, H Kozłowski, KS Kasprzak - Journal of Inorganic Biochemistry, 2000 - Elsevier
Nickel compounds are known human carcinogens, but the exact molecular mechanisms of
nickel carcinogenesis are not known. Due to their abundance, histones are likely targets for …
nickel carcinogenesis are not known. Due to their abundance, histones are likely targets for …
The possible role of 94− 125 peptide fragment of histone H2B in nickel-induced carcinogenesis
AM Nunes, K Zavitsanos, R Del Conte… - Inorganic …, 2010 - ACS Publications
The molecular mechanism by which nickel carcinogenicity is exerted is not fully understood.
However, it is believed to involve DNA damage and epigenetic effects in chromatin, resulting …
However, it is believed to involve DNA damage and epigenetic effects in chromatin, resulting …
Interactions of nickel (II) with histones. Stability and solution structure of complexes with CH3CO-Cys-Ala-Ile-His-NH2, a putative metal binding sequence of histone H3
W Bal, J Lukszo, M Jezowska-Bojczuk… - Chemical research in …, 1995 - ACS Publications
Nickel (II) compounds are established human carcinogens, but the molecular mechanisms
underlying their activity are only partially known. One mechanism may include mediation by …
underlying their activity are only partially known. One mechanism may include mediation by …
Interactions of Nickel(II) with Histones: Interactions of Nickel(II) with CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a Peptide Modeling the Potential Metal Binding Site in …
W Bal, J Lukszo, K Bialkowski… - Chemical research in …, 1998 - ACS Publications
A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni (II) binding to
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …
Nickel binding sites in histone proteins: Spectroscopic and structural characterization
Nickel compounds are included among human carcinogens, though the molecular events
related to them are not yet completely known. It has been proposed that the basic element …
related to them are not yet completely known. It has been proposed that the basic element …
Truncation, deamidation, and oxidation of histone H2B in cells cultured with nickel (II)
AA Karaczyn, F Golebiowski… - Chemical research in …, 2005 - ACS Publications
Molecular mechanisms of nickel-induced carcinogenesis include interactions of Ni (II)
cations with histones. Previously, we demonstrated in vitro and in cells that Ni (II) cleaved off …
cations with histones. Previously, we demonstrated in vitro and in cells that Ni (II) cleaved off …
The octapeptidic end of the C-terminal tail of histone H2A is cleaved off in cells exposed to carcinogenic nickel (II)
AA Karaczyn, W Bal, SL North, RM Bare… - Chemical research in …, 2003 - ACS Publications
We have demonstrated previously that Ni (II) binds to the C-terminal− TESHHKAKGK motif of
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …
Interactions of Nickel(II) with Histones: Enhancement of 2'-Deoxyguanosine Oxidation by Ni(II) Complexes with CH3CO-Cys-Ala-Ile-His-NH2, a Putative Metal …
W Bal, J Lukszo, KS Kasprzak - Chemical research in toxicology, 1996 - ACS Publications
Studies of 2 '-deoxyguanosine oxidation by hydrogen peroxide in the presence of CH3CO-
Cys-Ala-Ile-His-NH2 (CAIH) and/or NiCl2 have been carried out in 100 mM phosphate buffer …
Cys-Ala-Ile-His-NH2 (CAIH) and/or NiCl2 have been carried out in 100 mM phosphate buffer …
Nickel binding to histone H4
Nickel compounds influence carcinogenesis by interfering with a variety of cellular targets. It
has been found that nickel is a potent inhibitor in vivo of histone H4 acetylation, in both yeast …
has been found that nickel is a potent inhibitor in vivo of histone H4 acetylation, in both yeast …