Progress in chimerism analysis in childhood malignancies–the dilemma of biostatistical considerations and ethical implications

T Klingebiel, D Niethammer, K Dietz, P Bader - Leukemia, 2001 - nature.com
In recent years, considerable progress has been made in the analysis of hematopoietic
chimerism after allogeneic stem cell transplantation (SCT). The introduction of serial and …

Debate round-table: comments concerning chimerism studies

M Gonzalez, R Lopez-Perez, R Garcia-Sanz… - Leukemia, 2001 - nature.com
Allogeneic stem cell transplantation (allo-SCT) is the treatment of choice for many patients
with hematological malignancies, as well as some non-malignant hematological disorders …

Intensive monitoring of minimal residual disease and chimerism after allogeneic hematopoietic stem cell transplantation for acute leukemia in children

T Pincez, R Santiago, H Bittencourt, I Louis… - Bone Marrow …, 2021 - nature.com
Posttransplant leukemia detection before overt relapse is key to the success of
immunotherapeutic interventions, as they are more efficient when leukemia burden is low …

Hematopoietic chimerism after allogeneic stem cell transplantation: a comparison of quantitative analysis by automated DNA sizing and fluorescent in situ …

J Jółkowska, A Pieczonka, T Strabel, D Boruczkowski… - BMC Hematology, 2005 - Springer
Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed
mainly in patients with high-risk or advanced hematologic malignancies and congenital or …

[HTML][HTML] Prognostic utility of routine chimerism testing at 2 to 6 months after allogeneic hematopoietic cell transplantation

GI Mossallam, AM Kamel, B Storer, PJ Martin - Biology of Blood and …, 2009 - Elsevier
The utility of routine chimerism analysis as a prognostic indicator of subsequent outcomes
after allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning …

[HTML][HTML] Achievement of early complete donor chimerism in CD25+-activated leukocytes is a strong predictor of the development of graft-versus-host-disease after …

C Martínez-Laperche, V Noriega, M Kwon… - Experimental …, 2015 - Elsevier
Chimerism dynamics in bone marrow, peripheral blood (PB), and T lymphocytes (TL) has
been associated with the development of various complications after allogeneic stem-cell …

Mixed T cell lineage chimerism in acute leukemia/MDS using pre-emptive donor lymphocyte infusion strategy—Is it prognostic?—a single-center retrospective study

V Sheth, V Potter, H de Lavallade, S Gandhi… - Blood Cancer …, 2021 - nature.com
Pre-emptive DLI (pDLI) is an effective strategy in lowering the risk of relapse without
significantly increasing the risk of graft-versus-host disease (GVHD) in the case of T cell …

Chimerism analysis following nonmyeloablative stem cell transplantation

T Lion, F Watzinger - Myeloid Leukemia: Methods and Protocols, 2006 - Springer
Molecular monitoring of hematopoietic chimerism has become a routine diagnostic
approach in patients after allogeneic stem cell transplantation. Chimerism testing permits the …

Delayed attainment of full donor chimaerism following alemtuzumab‐based reduced‐intensity conditioning haematopoeitic stem cell transplantation for acute myeloid …

ZY Lim, L Pearce, AY Ho, L Barber… - British journal of …, 2007 - Wiley Online Library
This prospective study evaluated the kinetics of lymphoid (CD3) engraftment in 110 patients
with acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS) after allogeneic …

Reduced intensity conditioning and prophylactic DLI can cure patients with high-risk acute leukaemias if complete donor chimerism can be achieved

G Massenkeil, M Nagy, M Lawang, O Rosen… - Bone marrow …, 2003 - nature.com
23 patients with ALL (n= 9) and AML (n= 14) underwent nonmyeloablative stem cell
transplantation (NST) from an HLA-identical donor after conditioning with fludarabine (180 …