Reduced intensity conditioning and prophylactic DLI can cure patients with high-risk acute leukaemias if complete donor chimerism can be achieved
G Massenkeil, M Nagy, M Lawang, O Rosen… - Bone marrow …, 2003 - nature.com
23 patients with ALL (n= 9) and AML (n= 14) underwent nonmyeloablative stem cell
transplantation (NST) from an HLA-identical donor after conditioning with fludarabine (180 …
transplantation (NST) from an HLA-identical donor after conditioning with fludarabine (180 …
Increasing mixed chimerism defines a high-risk group of childhood acute myelogenous leukemia patients after allogeneic stem cell transplantation where pre-emptive …
P Bader, H Kreyenberg, W Hoelle… - Bone marrow …, 2004 - nature.com
Children with leukemias and increasing mixed chimerism (increasing MC) after allogeneic
stem cell transplantation have the highest risk to relapse. Early immunological intervention …
stem cell transplantation have the highest risk to relapse. Early immunological intervention …
Impact of day 14 peripheral blood chimerism after allogeneic hematopoietic stem cell bone transplantation on the treatment outcome of Non-Malignant Disease
YB Choi, JW Lee, KW Sung, HH Koo… - Journal of Korean …, 2019 - synapse.koreamed.org
Background The impact of early peripheral blood chimerism on the outcome of allogeneic
hematopoietic stem cell transplantation (allo-HSCT) is unclear. We aimed to determine …
hematopoietic stem cell transplantation (allo-HSCT) is unclear. We aimed to determine …
Chimerism evaluation in measurable residual disease‐suspected cells isolated by flow cell sorting as a reliable tool for measurable residual disease verification in …
A Semchenkova, V Brilliantova… - Cytometry Part B …, 2021 - Wiley Online Library
Background The presence of minimal/measurable residual disease (MRD) before or after
hematopoietic stem cell transplantation (HSCT) is known as a predictor of poor outcome in …
hematopoietic stem cell transplantation (HSCT) is known as a predictor of poor outcome in …
Monthly prospective analysis of hematopoietic chimerism after allogeneic hematopoietic cell transplantation
KH Lee, JH Lee, SJ Choi, S Kim, M Seol… - Bone marrow …, 2003 - nature.com
Hematopoietic chimerism (HpC) was assayed monthly using a sensitive, polymerase chain
reaction (PCR)-based method in consecutive patients. Between January 1998 and April …
reaction (PCR)-based method in consecutive patients. Between January 1998 and April …
[HTML][HTML] Chimerism studies in HLA-identical nonmyeloablative hematopoietic stem cell transplantation point to the donor CD8+ T-cell count on day+ 14 as a predictor …
SL Petersen, HO Madsen, LP Ryder… - Biology of Blood and …, 2004 - Elsevier
Chimerism analysis of hematopoietic cells has emerged as an essential tool in
nonmyeloablative hematopoietic stem cell transplantation. We have investigated the …
nonmyeloablative hematopoietic stem cell transplantation. We have investigated the …
Impact on outcomes of mixed chimerism of bone marrow CD34+ sorted cells after matched or haploidentical allogeneic stem cell transplantation for myeloid …
Y Le Bris, D Costes, R Bourgade, T Guillaume… - Bone Marrow …, 2022 - nature.com
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT), proposed to patients with
high-risk myeloid malignancies, may ultimately fail because of disease relapse. Bone …
high-risk myeloid malignancies, may ultimately fail because of disease relapse. Bone …
[HTML][HTML] Patterns of hematopoietic chimerism following bone marrow transplantation for childhood acute lymphoblastic leukemia from volunteer unrelated donors
K Molloy, N Goulden, M Lawler, J Cornish, A Oakhill… - Blood, 1996 - Elsevier
Hematopoietic chimerism was analyzed in serial bone marrow samples taken from 28
children following T-cell depleted unrelated donor bone marrow transplants (UD BMT) for …
children following T-cell depleted unrelated donor bone marrow transplants (UD BMT) for …
[HTML][HTML] Donor chimerism early after reduced-intensity conditioning hematopoietic stem cell transplantation predicts relapse and survival
The impact of early donor cell chimerism on outcomes of T cell–replete reduced-intensity
conditioning (RIC) hematopoietic stem cell transplantation (HSCT) is ill defined. We …
conditioning (RIC) hematopoietic stem cell transplantation (HSCT) is ill defined. We …
Monitoring of lineage-specific chimaerism allows early prediction of response following donor lymphocyte infusions for relapsed chronic myeloid leukaemia
N Gardiner, M Lawler, JM O'Riordan… - Bone marrow …, 1998 - nature.com
Donor lymphocyte infusions (DLI) have been shown to enhance the graft-versus-leukaemia
(GVL) effect and induce haematological and molecular remission in patients with relapsed …
(GVL) effect and induce haematological and molecular remission in patients with relapsed …