Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum

MT Tebano, A Martire, V Chiodi… - Journal of …, 2009 - Wiley Online Library
Abstract Adenosine A2A, cannabinoid CB1 and metabotropic glutamate 5 (mGlu5) receptors
are all highly expressed in the striatum. The aim of the present work was to investigate …

Pre‐synaptic adenosine A2A receptors control cannabinoid CB1 receptor‐mediated inhibition of striatal glutamatergic neurotransmission

A Martire, MT Tebano, V Chiodi… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 273–280. Abstract An interaction between adenosine A2A
receptors (A2ARs) and cannabinoid CB1 receptors (CB1Rs) has been consistently reported …

Striatal adenosine–cannabinoid receptor interactions in rats over‐expressing adenosine A2A receptors

V Chiodi, A Ferrante, L Ferraro… - Journal of …, 2016 - Wiley Online Library
Abstract Adenosine A2A receptors (A2 AR s) and cannabinoid CB 1 receptors (CB 1Rs) are
highly expressed in the striatum, where they functionally interact and form A2A/CB 1 …

Adenosine A2A–cannabinoid CB1 receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission

MT Tebano, A Martire, P Popoli - Brain research, 2012 - Elsevier
The striatum is a subcortical area involved in sensorimotor, cognitive and emotional
processes. Adenosine A2A receptors (A2ARs) are highly expressed in the striatum, and their …

Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor‐mediated inhibition of corticostriatal glutamatergic transmission

SG Ferreira, FQ Gonçalves, JM Marques… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Both cannabinoid CB 1 and adenosine A2A receptors (CB1
receptors and A2A receptors) control synaptic transmission at corticostriatal synapses, with …

Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum

E Moreno, A Chiarlone, M Medrano… - …, 2018 - nature.com
The dorsal striatum is a key node for many neurobiological processes such as motor activity,
cognitive functions, and affective processes. The proper functioning of striatal neurons relies …

Cannabinoid CB1 and adenosine A1 receptors independently inhibit hippocampal synaptic transmission

A Serpa, JA Ribeiro, AM Sebastião - European journal of pharmacology, 2009 - Elsevier
Adenosine A1 and cannabinoid CB1 receptors are affected by drugs widely consumed by
humans, as it is the case for caffeine, an adenosine receptor antagonist, and …

Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors

AF Hoffman, N Laaris, M Kawamura… - Journal of …, 2010 - Soc Neuroscience
Marijuana is a widely used drug that impairs memory through interaction between its
psychoactive constituent, Δ-9-tetrahydrocannabinol (Δ9-THC), and CB1 receptors (CB1Rs) …

Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum

M Orrú, C Quiroz, X Guitart, S Ferré - Neuropharmacology, 2011 - Elsevier
Adenosine A2A receptors (A2ARs) are highly concentrated in the striatum. Two
pharmacological different functional populations of A2ARs have been recently described …

Anandamide and WIN 55212‐2 inhibit cyclic AMP formation through G‐protein‐coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes

S Sagan, L Venance, Y Torrens… - European Journal of …, 1999 - Wiley Online Library
The effects of anandamide and the cannabinoid receptor agonists WIN 55212‐2 and CP
55940 on the evoked formation of cyclic AMP were compared in cultured neurons and …