Background Traumatic knee injuries in humans trigger an immediate increase in synovial
fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We …

Objective Osteoarthritis (OA) is a serious joint disease with no disease-modifying medical
treatment. To develop treatments targeting synovium, we must improve our understanding of …

Aim: Osteoarthritis (OA) is a whole joint pathology involving cartilage, synovial membrane,
meniscus, subchondral bone, and infrapatellar fat pad (IFP). Synovitis has been widely …

Purpose: Acute joint injuries from sports, exercise or accident-related trauma often progress
to post-traumatic Osteoarthritis (PTOA), comprising∼ 12% of all OA cases. Such joint …

Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and
progression of disease. Signs of inflammation can be observed in joint fluids and tissues …

Objective Although both cartilage and synovium are affected in osteoarthritis (OA), no in vitro
coculture models of human OA tissue have been described. The aim of this study was to …

Objective Since the joint microenvironment and tissue homeostasis are highly dependent on
synovial fluid, we aimed to compare the essential chondrocyte signaling signatures of non …

Introduction Acute trauma involving the anterior cruciate ligament is believed to be a major
risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In …

Objective Osteoarthritis (OA) is a multifactorial disease with etiological heterogeneity. The
objective of this study was to classify OA subgroups by generating metabolomic phenotypes …

Objective Evidence is accumulating that synovial tissue plays an active role in osteoarthritis
(OA), however, exact understanding of its contribution is lacking. In order to further elucidate …