Ceramides, structural components of the cell, are known to play a range of roles in glucose
metabolism and apoptosis. C16-ceramide, an abundant molecular species of endogenous …

To investigate signal transduction pathways leading to apoptosis during the early phase of
neurogenesis, we employed PCC7-Mz1 cells, which cease to proliferate and begin to …

Although aging is considered to be an unavoidable event, recent experimental evidence
suggests that the process can be counteracted. Intracellular calcium (Ca 2+ i) …

Increased long-chain C20: 0 ceramides have been found in the serum of patients with
depression. Moreover, ceramides are linked with increased microglia reactivity and …

Obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic steatohepatitis (NASH) can be
associated with cognitive impairment or early neurodegeneration. Previously, we showed …

Ceramide has been recognized as a second messenger that regulates several intracellular
processes in neuronal cells. However, its role in neuronal autophagy is not fully understood …

Obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic steatohepatitis (NASH) are
associated with cognitive impairment, brain insulin resistance, and neurodegeneration …

The discovery of ceramide kinase (CerK), which phosphorylates ceramide (Cer) to ceramide
1-phisphate (C1P), established a new pathway for Cer metabolism. Among mouse tissues …

One of the characteristics of ceramide-mediated biology is the variety of biological outcomes
observed in response to its intracellular accumulation. The molecular mechanisms that …

Ceramide accumulates in neurons during various disorders associated with acute or chronic
neurodegeneration. In these studies, we investigated the mechanisms of ceramide-induced …