A major goal in cancer and aging research is to discriminate the biochemical modifications
that happen locally that could account for the healthiness or malignancy of tissues …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Senescent cells are present in premalignant lesions and sites of tissue damage and
accumulate in tissues with age. In vivo identification, quantification and characterization of …

A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In
addition to mediators of age‐related pathology, components of the senescence associated …

Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …

Background Higher numbers of senescent cells have been implicated in age-related
disease pathologies. However, whether different diseases have different senescent …

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-
suppressive mechanism. However, due to the associated secretory phenotype senescence …