Painful neuropathy is common in human diabetes. In rats, experimental diabetes results in
altered pain sensitivity. We examined the effect of chronic insulin treatment on diabetes …

The triggers and pathogenesis of peripheral diabetic neuropathy are poorly understood, and
this study evaluated the role of insulinopenia in nociceptive abnormalities in the …

Pain in diabetes is a common debilitating condition for which pathophysiology remains
poorly understood. To evaluate the underlying mechanisms, we used intravenous injection …

A modified von Frey filament test and an algesiometer paw pressure test were used to
measure mechanical nociceptive withdrawal thresholds of the hind limb of control rats and …

The effect exerted by different hyperglycemic states on the pain threshold and on the
analgesic potential of morphine was studied in male Sabra rats with the hot plate device …

Streptozotocin (STZ)-induced diabetes in the rat has been increasingly used as a model of
painful diabetic neuropathy to assess the efficacies of potential analgesic agents. We have …

Painful peripheral neuropathy is a common secondary complication of diabetes. The
streptozotocin (STZ)‐induced diabetic rat is the most commonly employed animal model …

Insulin-dependent diabetes mellitus (IDDM) is associated with several complications,
including painful diabetic neuropathy. Both animal and human investigations suggest an …

Abstract Objective. As the Diabetes Control and Complications Trial showed that intensive
glycemic control in patients with Type 1 diabetes decreased the risk of development of long …

Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the
mechanisms underlying this symptom, it was studied and compared in rat models of …