Abstract Editor's Perspective What We Already Know about This Topic The mechanisms
supporting bone cancer pain are incompletely understood Stress of the endoplasmic …

Background Management of bone cancer pain is difficult because of its complex
mechanisms, which has a major impact on the quality of patients' daily life. Recent studies …

Background Endoplasmic reticulum stress plays a crucial role in the pathogenesis of
neuroinflammation and chronic pain. This study hypothesized that PRKR-like endoplasmic …

Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but
its role in neuropathic pain remains unclear. In this study, we examined the ER stress and …

Background Activation of adenosine monophosphate–activated kinase (AMPK) has been
associated with the inhibition of inflammatory nociception and the attenuation of morphine …

Background Although inflammation induces pain, immune cells also produce mediators that
can effectively counteract it. To further elucidate the role of the immune response, we …

Abstract Editor's Perspective What We Already Know about This Topic Pain resulting from
cancer metastatic to bone is a major clinical problem Vascular endothelial growth factor …

Background: Ethyl pyruvate (EP) possesses anti-inflammatory activity. However, the
potential anti-nociceptive value of EP for the treatment of the inflammatory nociception is …

Background The anterior cingulate cortex (ACC) is a brain region that has been critically
implicated in the processing of pain perception and modulation. While much evidence has …

Background Endoplasmic reticulum (ER) stress is involved in many neurological and
inflammatory responses. Peripheral inflammatory responses can induce central sensitization …