Background Cellular interior is known to be densely crowded due to the presence of soluble
and insoluble macromolecules, which altogether occupy~ 40% of the total cellular volume …

Atomistic molecular dynamics simulations of concentrated protein solutions in the presence
of a phospholipid bilayer are presented to gain insights into the dynamics and interactions at …

More than 60 years of biochemical and biophysical studies have accustomed us to think of
proteins as highly purified entities that act in isolation, more or less freely diffusing until they …

Folding, curvature, and domain formation are characteristics of many biological membranes.
Yet the mechanisms that drive both curvature and the formation of specialized domains …

Highlights•Membrane reshaping in the cell, such as during trafficking, endocytosis, division
and other phenomena, is highly dynamic and typically involves a multitude of components …

The plasma membrane's main constituents, ie, phospholipids and membrane proteins, are
known to be organized in lipid-protein functional domains and supercomplexes. No active …

Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it
is indispensable to take into account various interactions between the protein and other …

Coarse-grained molecular dynamics simulations of the E. coli outer membrane proteins
FhuA, LamB, NanC, OmpA and OmpF in a POPE/POPG (3∶ 1) bilayer were performed to …

Cells are highly crowded with proteins and polynucleotides. Any reaction that depends on
the available volume can be affected by macromolecular crowding, but the effects of …

Membranes are the defining envelopes of living cells. At this boundary a multitude of
transmembrane proteins mediate signal and mass transfer between cells and their …