Macromolecular crowding has long been known to significantly affect protein
oligomerization, and yet no direct quantitative measurements appear to have been made of …

Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …

Peripheral proteins can bend membranes through several different mechanisms, including
scaffolding, wedging, oligomerization, and crowding. The crowding effect in particular has …

Conspectus Any chemist studying the interaction of molecules with lipid assemblies will
eventually be confronted by the topic of membrane bilayer heterogeneity and may ultimately …

Single molecule techniques promise novel information about the properties and behavior of
individual particles, thus enabling access to molecular heterogeneities in biological systems …

The dynamic lateral segregation of signaling proteins into microdomains is proposed to
facilitate signal transduction, but the constraints on microdomain size, mobility, and diffusion …

Folding and packing of membrane proteins are highly influenced by the lipidic component of
the membrane. Here, we explore how the hydrophobic mismatch (the difference between …

During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …

Molecular transport between organelles is predominantly governed by vesicle fission and
fusion. Unlike experimental vesicles, the fused vesicles in molecular dynamics simulations …

Previous experiments with two single-domain proteins showed that macromolecular
crowding can stabilize dramatically toward heat perturbation and modulate native-state …