Abstract Alpha‐1 antitrypsin (AAT) deficiency is an under‐recognized hereditary disorder
associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis …

Objective To review the topic of alpha-1 antitrypsin (AAT) deficiency. Method Narrative
literature review. Results Much work has been carried out on this condition with many …

Alpha-1-antitrypsin (A1AT) deficiency is an autosomal hereditary disorder associated with a
major reduction in serum A1AT levels. Clinically, A1AT deficiency is associated with …

Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. The typical
pulmonary manifestation is chronic obstructive pulmonary disease and emphysema. Severe …

Summary Alpha‐1 antitrypsin (A1AT) is a serine anti‐protease produced chiefly by the liver.
A1AT deficiency is a genetic disorder characterized by serum levels of less than 11 μmol/L …

Background Alpha-1 antitrypsin deficiency (AATD) is a rare hereditary condition that leads to
decreased circulating alpha-1 antitrypsin (AAT) levels, significantly increasing the risk of …

ABSTRACT α1-antitrypsin (α1AT) deficiency is a common lethal hereditary disorder of white
persons of European descent. The condition is characterized by reduced serum levels of α …

Background: Laboratory testing in suspected α-1-antitrypsin (A1AT) deficiency involves
analysis of A1AT concentrations and identification of specific alleles by genotyping or …

Abstract Alpha-1 antitrypsin Deficiency (AATD) is a common, but under recognized
metabolic genetic disease. Although many mutations in the alpha-1 antitrypsin (AAT) gene …

Since the first American Thoracic Society statement regarding the diagnosis and
management of severe alpha-1 antitrypsin (AAT) deficiency in 1989 (1) and the initial …