New pyrimidine-5-carbonitrile derivatives as EGFR inhibitors with anticancer and apoptotic activities: design, molecular modeling and synthesis
IA Osman, RR Ayyad, HA Mahdy - New Journal of Chemistry, 2022 - pubs.rsc.org
In connection with our efforts in the development of new anticancer agents, herein we report
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors
Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
Structure based design and anti-breast cancer evaluation of some novel 4-anilinoquinazoline derivatives as potential epidermal growth factor receptor inhibitors
Z Haghighijoo, Z Rezaei, M Jaberipoor… - Research in …, 2018 - journals.lww.com
Quinazoline is one of the most widespread scaffolds amongst natural and synthetic bioactive
compounds. Recently the quinazoline derivatives and in particular the 4-anilinoquinazolines …
compounds. Recently the quinazoline derivatives and in particular the 4-anilinoquinazolines …
Design, synthesis and structure-activity relationships of novel diaryl urea derivatives as potential EGFR inhibitors
N Jiang, Y Bu, Y Wang, M Nie, D Zhang, X Zhai - Molecules, 2016 - mdpi.com
Two novel series of diaryl urea derivatives 5a–i and 13a–l were synthesized and evaluated
for their cytotoxicity against H-460, HT-29, A549, and MDA-MB-231 cancer cell lines in vitro …
for their cytotoxicity against H-460, HT-29, A549, and MDA-MB-231 cancer cell lines in vitro …
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Y Le, Y Gan, Y Fu, J Liu, W Li, X Zou… - Journal of enzyme …, 2020 - Taylor & Francis
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed,
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing oxazole or imidazole as potential EGFR inhibitors
Y OuYang, C Wang, B Zhao, H Xiong, Z Xiao… - New Journal of …, 2018 - pubs.rsc.org
Six series of quinazoline derivatives bearing oxazole or imidazole (8a–f, 9a–f, 10a–d, 11a–f,
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …
Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities …
Y Zhang, Q Wang, L Li, Y Le, L Liu, J Yang… - Journal of Enzyme …, 2021 - Taylor & Francis
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and
studied the preliminary structure-activity relationship for antiproliferative activities. All target …
studied the preliminary structure-activity relationship for antiproliferative activities. All target …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-tetrahydroquinoline as potential …
Y OuYang, W Zou, L Peng, Z Yang, Q Tang… - European Journal of …, 2018 - Elsevier
Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
Synthesis and evaluation of new 4 (3H)-Quinazolinone derivatives as potential anticancer agents
A series of new 4 (3H)-quinazolinones were synthesized and evaluated for their cytotoxic
activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 …
activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 …