Design, synthesis, docking, ADMET and anticancer evaluations of N-alkyl substituted iodoquinazoline derivatives as dual VEGFR-2 and EGFR inhibitors
Fifteen new 1-alkyl-6-iodoquinazoline derivatives 5a–d to 9a–e were designed and
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …
Design and synthesis of 4, 6-substituted-(diaphenylamino) quinazolines as potent EGFR inhibitors with antitumor activity
HQ Li, DD Li, X Lu, YY Xu, HL Zhu - Bioorganic & medicinal chemistry, 2012 - Elsevier
A type of novel 4, 6-substituted-(diaphenylamino) quinazolines, which designed based on
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …
Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors
We report here the design and synthesis of a series of 4-anilinoquinazoline derivatives, of
which 7 compounds were crystallographically characterized, as epidermal growth factor …
which 7 compounds were crystallographically characterized, as epidermal growth factor …
Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity
YY Xu, SN Li, GJ Yu, QH Hu, HQ Li - Bioorganic & medicinal chemistry, 2013 - Elsevier
Two new series of new compounds containing a 6-amino-substituted group or 6-acrylamide-
substituted group linked to a 4-anilinoquinazoline nucleus have been discovered as …
substituted group linked to a 4-anilinoquinazoline nucleus have been discovered as …
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives
S Mowafy, A Galanis, ZM Doctor, RM Paranal… - Bioorganic & medicinal …, 2016 - Elsevier
A new series of 4-anilinoquinazolines with C-6 ureido and thioureido side chains and
various substituents at the C-4 anilino moiety was designed, synthesized and evaluated as …
various substituents at the C-4 anilino moiety was designed, synthesized and evaluated as …
Synthesis and Anti-Cancer Activity of New Pyrazolinyl-Indole Derivatives: Pharmacophoric Interactions and Docking Studies for Identifying New EGFR Inhibitors
H Khalilullah, DK Agarwal, MJ Ahsan… - International Journal of …, 2022 - mdpi.com
Newly designed series of indole-containing pyrazole analogs, pyrazolinylindoles, were
synthesized, and their structures were confirmed based on the spectral data of the 1H NMR …
synthesized, and their structures were confirmed based on the spectral data of the 1H NMR …
Design, synthesis and in vitro anti-proliferative activity of 4, 6-quinazolinediamines as potent EGFR-TK inhibitors
4-Anilino-6-substituted-quinazolines were designed, synthesized and evaluated for EGFR-
TK and tumor growth inhibitory activities. The target compounds were designed with …
TK and tumor growth inhibitory activities. The target compounds were designed with …
Novel sulfonyl thiazolyl-hydrazone derivatives as EGFR inhibitors: Design, synthesis, biological evaluation and molecular docking studies
TA Farghaly, EMH Abbas, AM Al-Soliemy, R Sabour… - Bioorganic …, 2022 - Elsevier
New hydrazonoyl-sulfonylthiazoles were designed and synthesized as EGFR inhibitors. The
new sulfonylthiazole derivatives were assessed in vitro to measure their effect on EGFR …
new sulfonylthiazole derivatives were assessed in vitro to measure their effect on EGFR …
The combination of 4-anilinoquinazoline and cinnamic acid: A novel mode of binding to the epidermal growth factor receptor tyrosine kinase
DD Li, PC Lv, H Zhang, HJ Zhang, YP Hou, K Liu… - Bioorganic & medicinal …, 2011 - Elsevier
A novel type of cinnamic acid quinazoline amide derivatives (20–42), which designed the
combination between quinazoline as the backbone and various substituted cinnamic acid as …
combination between quinazoline as the backbone and various substituted cinnamic acid as …
Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant …
MA Shaheen, AA El-Emam, NS El-Gohary - Bioorganic Chemistry, 2020 - Elsevier
New series of hexahydroquinoline and fused quinoline derivatives were designed and
synthesized. The thirty seven new compounds were screened for in vitro antitumor activity …
synthesized. The thirty seven new compounds were screened for in vitro antitumor activity …