Synthesis, characterization of some pyrazine derivatives as anti-cancer agents: In vitro and in Silico approaches
ES Tantawy, AM Amer, EK Mohamed… - Journal of Molecular …, 2020 - Elsevier
In continuation of our interest on the synthesis of fused quinoxalines and pyrazines
derivatives and due to the resultant pharmacological interest in compounds which belong to …
derivatives and due to the resultant pharmacological interest in compounds which belong to …
Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis
The in vitro cytotoxicity of some substituted quinazolinones, 1–15, was evaluated using NCI
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …
Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity
AAM Eissa, KFM Aljamal, HS Ibrahim, HA Allam - Bioorganic Chemistry, 2021 - Elsevier
The present study describes the synthesis of three series of 4-substituted pyridopyrimidin
derivatives 4a-h, 5a-d. 6a-d, starting from 2-amino-6-(4-methoxyphenyl)-4-(4-(substituted) …
derivatives 4a-h, 5a-d. 6a-d, starting from 2-amino-6-(4-methoxyphenyl)-4-(4-(substituted) …
Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells
RSM Ismail, SM Abou-Seri, WM Eldehna… - European Journal of …, 2018 - Elsevier
Epidermal growth factor receptor (EGFR) signaling pathway has been previously
investigated for its significant role in the progression of different types of malignant tumors …
investigated for its significant role in the progression of different types of malignant tumors …
Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide …
S Mehta, S Kumar, RK Marwaha, B Narasimhan… - BMC chemistry, 2019 - Springer
In the present study, a series of 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-
oxoquinazolin-3 (4 H)-yl) acetamide derivatives was synthesized and its chemical structures …
oxoquinazolin-3 (4 H)-yl) acetamide derivatives was synthesized and its chemical structures …
Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents
A series of quinazolinone derivatives (7a–7h) were synthesized as antiproliferative agents.
All compounds, were synthesized through three steps method and structurally evaluated by …
All compounds, were synthesized through three steps method and structurally evaluated by …
2-(Chloromethyl)-3-phenylquinazolin-4 (3H)-ones as potent anticancer agents; cytotoxicity, molecular docking and in silico studies
In order to show antiproliferation and cancerous cell growth inhibition of quinazoline
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …
Synthesis, characterization, anticancer and antibacterial activity of some novel pyrano [2, 3-d] pyrimidinone carbonitrile derivatives
OS Aremu, K Gopaul, P Kadam… - Anti-Cancer Agents …, 2017 - ingentaconnect.com
Background: Pyrimidines have widespread activity and have shown potent antibacterial and
anticancer activity. Objective: To synthesise a range of pyrimidine diones and test them for …
anticancer activity. Objective: To synthesise a range of pyrimidine diones and test them for …
Design, synthesis, and antiproliferative activities of novel substitutedhydrazone/triazolo-linked quinazoline derivatives
A series of novel hydrazonoquinazolines and triazoloquinazolines analogues of Erlotinib
were synthesized and evaluated for their antiproliferative as well as EGFR kinase inhibitory …
were synthesized and evaluated for their antiproliferative as well as EGFR kinase inhibitory …
Design, synthesis, cytotoxic evaluation and molecular docking of new fluoroquinazolinones as potent anticancer agents with dual EGFR kinase and tubulin …
A series of new fluoroquinazolinone 6–8 and 10a–g derivatives was designed, prepared
and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and …
and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and …