[PDF][PDF] Optimisation of sample preparation for direct SPME-GC-MS analysis of murine and human faecal volatile organic compounds for metabolomic studies

S Reade, A Mayor, R Aggio, T Khalid… - J Anal Bioanal …, 2014 - researchgate.net
The analysis of volatile organic compounds (VOCs) emitted from biological fluids such as
blood, urine, breath and faeces, has been receiving more attention from researchers and …

Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)

S Zhang, D Raftery - Mass Spectrometry in Metabolomics: Methods and …, 2014 - Springer
In this chapter, we describe the procedure for metabolic profiling of hundreds of urinary
volatile organic compounds (VOCs) using headspace solid-phase microextraction (SPME) …

[HTML][HTML] Solid-phase microextraction and the human fecal VOC metabolome

E Dixon, C Clubb, S Pittman, L Ammann, Z Rasheed… - PloS one, 2011 - journals.plos.org
The diagnostic potential and health implications of volatile organic compounds (VOCs)
present in human feces has begun to receive considerable attention. Headspace solid …

[HTML][HTML] Freeze-drying: an alternative method for the analysis of volatile organic compounds in the headspace of urine samples using solid phase micro-extraction …

RBM Aggio, A Mayor, S Coyle, S Reade… - Chemistry Central …, 2016 - Springer
Abstract Background Volatile organic compounds (VOCs) can be intermediates of metabolic
pathways and their levels in biological samples may provide a better understanding about …

[HTML][HTML] The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome

RD Couch, K Navarro, M Sikaroodi, P Gillevet… - PloS one, 2013 - journals.plos.org
Recent studies have illustrated the importance of the microbiota in maintaining a healthy
state, as well as promoting disease states. The intestinal microbiota exerts its effects …

[HTML][HTML] Optimized sample preparation for fecal volatile organic compound analysis by gas chromatography–mass spectrometry

S el Manouni el Hassani, RJ Soers, DJC Berkhout… - Metabolomics, 2020 - Springer
Introduction Headspace gas chromatography–mass spectrometry (HS-GC–MS) is widely
considered the gold standard of quantitative fecal VOC analysis. However, guidelines …

[HTML][HTML] Evaluation of different stool extraction methods for metabolomics measurements in human faecal samples

V Erben, G Poschet, P Schrotz-King… - … Nutrition, Prevention & …, 2021 - ncbi.nlm.nih.gov
Background Metabolomics analysis of human stool samples is of great interest for a broad
range of applications in biomedical research including early detection of colorectal …

A review on human fecal metabolomics: Methods, applications and the human fecal metabolome database

N Karu, L Deng, M Slae, AC Guo, T Sajed, H Huynh… - Analytica chimica …, 2018 - Elsevier
Metabolomic analysis of human biospecimens had progressed quickly over the past
decade. Technological and methodological advances have led to the comprehensive …

[HTML][HTML] Application of fecal volatile organic compound analysis in clinical practice: Current state and future perspectives

S El Manouni el Hassani, DJC Berkhout, S Bosch… - Chemosensors, 2018 - mdpi.com
Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as
non-invasive diagnostic biomarker in clinical medical practice. The spectrum of VOCs …

[HTML][HTML] An optimised monophasic faecal extraction method for LC-MS analysis and its application in gastrointestinal disease

PE Kelly, HJ Ng, G Farrell, S McKirdy, RK Russell… - Metabolites, 2022 - mdpi.com
Liquid chromatography coupled with mass spectrometry (LC-MS) metabolomic approaches
are widely used to investigate underlying pathogenesis of gastrointestinal disease and …