The extracellular calcium-sensing receptor (CaR), a G protein-coupled receptor that resides
on the parathyroid cell surface negatively regulates secretion of parathyroid hormone (PTH) …

The extracellular calcium-sensing receptor (CaR) originally cloned from bovine parathyroid
gland is a G protein-coupled receptor. The physiological relevance of the cloned CaR for …

The extracellular calcium (Ca 2+ o)-sensing receptor (CaR) can be potentiated by allosteric
activators including calcimimetics andl-amino acids. In this study, we found that many …

Calcium-sensing receptors (CaSRs) are class CG protein-coupled receptors that respond to
physiological activators, including extracellular Ca2+ (Cao2+) and l-amino acids as well as …

Parathyroid hormone (PTH) secreted from parathyroid cells is a key regulator of circulating
levels of calcium ion, which is maintained within a narrow physiological range mainly by the …

Calcium sensing receptors (CaR) are unique among G‐protein–coupled receptors (GPCRs)
since both the first (extracellular) and second (intracellular) messengers are Ca 2+. CaR …

The divalent mineral cations Ca2+ and Mg2+ play many and diverse roles both in the
function of cells and in extracellular processes. The metabolism of these cations is a …

Extracellular calcium/polyvalent cation-sensing receptors (CaR) couple to G proteins and
contain highly conserved extracellular cysteine residues. Immunoblotting of proteins from rat …

Extracellular Ca2+-sensing receptors (CaRs) are the molecular basis by which specialized
cells detect and respond to changes in the extracellular [Ca2+]([Ca2+] o). CaRs belong to …

Publisher Summary A body of indirect evidence had suggested the presence of a Ca 2+ o-
sensing mechanism in parathyroid cells, C-cells, and kidney cells, through which Ca 2+ o …