The extracellular calcium ion (Ca2+ e)-sensing receptor (CaR) enables key tissues that
maintain Ca2+ e homeostasis to sense changes in the Ca2+ e concentration. These tissues …

G protein-coupled receptors (GPCRs) are the most common targets of drug action. Allosteric
modulators bind to the seven-transmembrane domain of family 3 GPCRs and offer …

In this article we consider the molecular basis of sensing and signalling by the extracellular
calcium‐sensing receptor. We consider the nature of its ligands and sensing modalities, the …

Daniela Riccardi has always been fascinated with how cells sense changes in their
environment and their responses at the molecular and cellular through to whole-organism …

Introduction 3. Biochemical and physiological features of the CaR 3.1. CaR agonists 3.2.
Physiology 3.3. Non-homeostatic functions of the CaR 3.4. Intracellular signal transduction …

Publisher Summary This chapter reviews the progress made in the discovery and
development of small molecules that activate or inhibit the parathyroid Ca 2+ receptor and …

The recent cloning of an extracellular calcium (Ca 2+ o)-sensing receptor (CaR) from the
parathyroid gland and the kidney has provided novel insights into the mechanisms that …

The extracellular calcium (Ca _ o^ 2+)-sensing receptor (CaSR) was the first GPCR
identified whose principal physiological ligand is an ion, namely extracellular Ca 2+. It …

The human Ca2+ receptor (hCaR) is a member of the superfamily of G protein-coupled
receptors. Its large (∼ 600 residue) amino-terminal extracellular domain contains 9 potential …

The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of
a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating …