Iron and oxidizing species in oxidative stress and Alzheimer's disease
Z Zhao - Aging Medicine, 2019 - Wiley Online Library
Iron species can participate in the Fenton or Fenton‐like reaction to generate oxidizing
species that can cause oxidative damages to biomolecules and induce oxidative stress in …
species that can cause oxidative damages to biomolecules and induce oxidative stress in …
Dysregulation of iron homeostasis in the central nervous system and the role of ferroptosis in neurodegenerative disorders
Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …
Iron and Alzheimer's disease: an update on emerging mechanisms
Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …
However, iron's biological utility as an effective redox cycling metal also endows it with the …
Iron dyshomeostasis and ferroptosis: a new Alzheimer's disease hypothesis?
F Wang, J Wang, Y Shen, H Li, WD Rausch… - Frontiers in aging …, 2022 - frontiersin.org
Iron plays a crucial role in many physiological processes of the human body, but iron is
continuously deposited in the brain as we age. Early studies found iron overload is directly …
continuously deposited in the brain as we age. Early studies found iron overload is directly …
Iron dysregulation in mitochondrial dysfunction and Alzheimer's disease
JO Onukwufor, RT Dirksen, AP Wojtovich - Antioxidants, 2022 - mdpi.com
Alzheimer's disease (AD) is a devastating progressive neurodegenerative disease
characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron …
characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron …
Iron and ferroptosis more than a suspect: beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and …
M Cerasuolo, I Di Meo, MC Auriemma, F Trojsi… - International Journal of …, 2023 - mdpi.com
Neurodegeneration is a multifactorial process that involves multiple mechanisms. Examples
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …
Iron: the Redox-active center of oxidative stress in Alzheimer disease
Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …
Iron in Alzheimer's disease: From physiology to disease disabilities
A Pal, G Cerchiaro, I Rani, M Ventriglia, M Rongioletti… - Biomolecules, 2022 - mdpi.com
Reactive oxygen species (ROS) play a key role in the neurodegeneration processes.
Increased oxidative stress damages lipids, proteins, and nucleic acids in brain tissue, and it …
Increased oxidative stress damages lipids, proteins, and nucleic acids in brain tissue, and it …
Oxidative stress and neurodegeneration: the involvement of iron
A Carocci, A Catalano, MS Sinicropi, G Genchi - Biometals, 2018 - Springer
Many evidences indicate that oxidative stress plays a significant role in a variety of human
disease states, including neurodegenerative diseases. Iron is an essential metal for almost …
disease states, including neurodegenerative diseases. Iron is an essential metal for almost …
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
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