Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

The accumulation of transition metals (eg, copper, zinc, and iron) and the dysregulation of
their metabolism are a hallmark in the pathogenesis of several neurodegenerative diseases …

Iron is an essential element for life on earth, participating in a plethora of cellular processes
where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in …

Alzheimer's disease (AD) accounts for two-thirds of all dementia cases, affecting 50 million
people worldwide. Only four of the more than 100 AD drugs developed thus far have …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

As people age, iron deposits in different areas of the brain may impair normal cognitive
function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the …

Brain iron accumulation has been implicated in a host of chronic neurological diseases,
including Parkinson's disease (PD). The elevated iron levels observed in the substantia …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's,
Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of …

Iron is an essential element for multiple functions of the brain. Maintenance of iron
homeostasis involves regulation of iron influx, iron efflux and iron storage. Mismanagement …