The development of biological therapies has improved management of rheumatoid arthritis.
However, costs and unresponsiveness to therapy in a sizeable proportion of patients limit …

Proopiomelanocortin-derived peptides exert pleiotropic effects via binding to melanocortin
receptors (MCR). MCR-subtypes have been detected in cartilage and bone and mediate an …

BACKGROUND AND PURPOSE Melanocortin MC1 and MC3 receptors, mediate the anti‐
inflammatory effects of melanocortin peptides. Targeting these receptors could therefore …

Human melanocortin MC1 and MC3 receptors expressed on C-20/A4 chondrocytes exhibit
chondroprotective and anti-inflammatory effects when activated by melanocortin peptides …

Objective The pro‐opiomelanocortin (POMC)–derived neuropeptide α‐melanocyte–
stimulating hormone (α‐MSH) mediates its effects via melanocortin (MC) receptors. This …

Background Melanocortins are peptides endowed with anti-inflammatory and pro-resolving
activities. Many of these effects are mediated by the Melanocortin receptor 1 (MC1) as …

Because there is clinical evidence for an association between periodontal disease and
rheumatoid arthritis, it is important to develop suitable experimental models to explore …

Objective To test the hypothesis that local activation of melanocortin receptor (s) by
adrenocorticotropic hormone (ACTH) could be responsible, at least in part, for its efficacy in …

The resolution of inflammation is now known to be an active process, armed with a multitude
of mediators both lipid and protein in nature. Melanocortins are peptides endowed with …

Arthritic pathologies are a major cause of morbidity within the western world, with
rheumatoid arthritis affecting approximately 1% of adults. This review highlights the …