With very few exceptions, all adult tissues in mammals are maintained and can be renewed
by stem cells that self-renew and generate the committed progeny required. These functions …

Bone-related maladies are a major health burden on modern society. Loss of skeletal
integrity and regeneration capacity through aging, obesity, and disease follows from a …

Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time.
One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton …

Lineage commitment and differentiation of skeletal stem cells/bone marrow stromal cells
(SSCs/BMSCs, often called bone marrow-derived “mesenchymal stem/stromal” cells) offer …

Human skeletal stem cells (hSSCs) hold tremendous therapeutic potential for developing
new clinical strategies to effectively combat congenital and age-related musculoskeletal …

Bone marrow (BM) contains stem cells for both hematopoietic and nonhematopoietic
lineages. Hematopoietic stem cells enable hematopoiesis to occur in a controlled manner in …

Abstract Purpose of Review Skeletal stem cells (SSCs) are considered to play important
roles in bone development and repair. These cells have been historically defined by their in …

Populations of bone marrow stromal cells (BMSCs, also known as bone marrow-derived
“mesenchymal stem cells”) contain a subset of cells that are able to recapitulate the …

Skeletal stem/progenitor cells (SSPCs), characterized by self-renewal and multipotency, are
essential for skeletal development, bone remodeling, and bone repair. These cells have …

Skeletal stem cells (SSCs) generate the progenitors needed for growth, maintenance and
repair of the skeleton. Historically, SSCs have been defined as bone marrow-derived cells …