A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder

B Hing, L Sathyaputri, JB Potash - American Journal of Medical …, 2018 - Wiley Online Library
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …

[HTML][HTML] A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity

B Hing, S Davidson, M Lear, G Breen, J Quinn… - Biological …, 2012 - Elsevier
BACKGROUND: Changes in brain derived neurotrophic factor (BDNF) expression have
been associated with mood disorders and cognitive dysfunction. Transgenic models that …

New insights on brain‐derived neurotrophic factor epigenetics: from depression to memory extinction

CH Poon, BC Heng, LW Lim - … of the New York Academy of …, 2021 - Wiley Online Library
Advances in characterizing molecular profiles provide valuable insights and opportunities
for deciphering the neuropathology of depression. Although abnormal brain‐derived …

Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants

F Duclot, M Kabbaj - Journal of Experimental Biology, 2015 - journals.biologists.com
Major depressive disorder (MDD) is a devastating neuropsychiatric disorder encompassing
a wide range of cognitive and emotional dysfunctions. The prevalence of MDD is expected …

[HTML][HTML] BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects

X Jiang, K Xu, J Hoberman, F Tian, AJ Marko… - …, 2005 - nature.com
The brain-derived neurotrophic factor (BDNF) gene is critical for neuronal function and
survival, and is likely to be important in psychiatric disorders. In this study, we used single …

Epigenetic regulation of the BDNF gene: implications for psychiatric disorders

F Boulle, DLA Van Den Hove, SB Jakob… - Molecular …, 2012 - nature.com
Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in
the course and development of various neurological and psychiatric disorders. In addition …

[HTML][HTML] BDNF genetic variants and methylation: effects on cognition in major depressive disorder

A Ferrer, J Labad, N Salvat-Pujol, M Barrachina… - Translational …, 2019 - nature.com
Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the
pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits …

Epigenetic regulation of BDNF expression according to antidepressant response

JP Lopez, F Mamdani, B Labonte, MM Beaulieu… - Molecular …, 2013 - nature.com
Several lines of evidence support the role of brain-derived neurotrophic factor (BDNF) in the
pathophysiology and pharmacotherapy of depression. 1 The neurotrophin hypothesis of …

Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants

H Yu, DD Wang, Y Wang, T Liu, FS Lee… - Journal of …, 2012 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) plays important roles in cell survival, neural
plasticity, learning, and stress regulation. However, whether the recently found human BDNF …

Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …