A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …
[HTML][HTML] A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity
BACKGROUND: Changes in brain derived neurotrophic factor (BDNF) expression have
been associated with mood disorders and cognitive dysfunction. Transgenic models that …
been associated with mood disorders and cognitive dysfunction. Transgenic models that …
New insights on brain‐derived neurotrophic factor epigenetics: from depression to memory extinction
Advances in characterizing molecular profiles provide valuable insights and opportunities
for deciphering the neuropathology of depression. Although abnormal brain‐derived …
for deciphering the neuropathology of depression. Although abnormal brain‐derived …
Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants
F Duclot, M Kabbaj - Journal of Experimental Biology, 2015 - journals.biologists.com
Major depressive disorder (MDD) is a devastating neuropsychiatric disorder encompassing
a wide range of cognitive and emotional dysfunctions. The prevalence of MDD is expected …
a wide range of cognitive and emotional dysfunctions. The prevalence of MDD is expected …
[HTML][HTML] BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
X Jiang, K Xu, J Hoberman, F Tian, AJ Marko… - …, 2005 - nature.com
The brain-derived neurotrophic factor (BDNF) gene is critical for neuronal function and
survival, and is likely to be important in psychiatric disorders. In this study, we used single …
survival, and is likely to be important in psychiatric disorders. In this study, we used single …
Epigenetic regulation of the BDNF gene: implications for psychiatric disorders
F Boulle, DLA Van Den Hove, SB Jakob… - Molecular …, 2012 - nature.com
Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in
the course and development of various neurological and psychiatric disorders. In addition …
the course and development of various neurological and psychiatric disorders. In addition …
[HTML][HTML] BDNF genetic variants and methylation: effects on cognition in major depressive disorder
A Ferrer, J Labad, N Salvat-Pujol, M Barrachina… - Translational …, 2019 - nature.com
Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the
pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits …
pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits …
Epigenetic regulation of BDNF expression according to antidepressant response
Several lines of evidence support the role of brain-derived neurotrophic factor (BDNF) in the
pathophysiology and pharmacotherapy of depression. 1 The neurotrophin hypothesis of …
pathophysiology and pharmacotherapy of depression. 1 The neurotrophin hypothesis of …
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants
H Yu, DD Wang, Y Wang, T Liu, FS Lee… - Journal of …, 2012 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) plays important roles in cell survival, neural
plasticity, learning, and stress regulation. However, whether the recently found human BDNF …
plasticity, learning, and stress regulation. However, whether the recently found human BDNF …
Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders
M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …