Dying cells are capable of activating the innate immune system and inducing a sterile
inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 …

Cells undergoing necrosis release endogenous danger signals that possess
proinflammatory potential. In this study we show that mature IL-1β and IL-18 are released by …

In response to infection or cell damage, inflammasomes form intracellular multimeric protein
complexes that play an essential role in host defense. Activation results in the maturation …

The NLRP3 inflammasome is a critical component of the innate immune system. NLRP3
activation is induced by diverse stimuli associated with bacterial infection or tissue damage …

Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia.
The importance of negative regulation of NLRP3 inflammasomes remains poorly …

In response to inflammatory stimuli, immune cells reconfigure their metabolism and
bioenergetics to generate energy and substrates for cell survival and to launch immune …

ABSTRACT The NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation
of the inflammatory response causes oxidative stress, alterations in mitochondrial energy …

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

Innate immune cells rely on pathogen recognition receptors such as the nucleotide-binding
and oligomerization domain (NOD)-like receptor (NLR) family to mount an appropriate …