Botulinum toxin conditioning enhances motor axon regeneration in mouse and human preclinical models

CK Franz, A Puritz, LA Jordan, J Chow… - … and neural repair, 2018 - journals.sagepub.com
Background. Peripheral axon regeneration is improved when the nerve lesion under
consideration has recently been preceded by another nerve injury. This is known as the …

Botulinum neurotoxin A promotes functional recovery after peripheral nerve injury by increasing regeneration of myelinated fibers

S Cobianchi, J Jaramillo, S Luvisetto, F Pavone… - Neuroscience, 2017 - Elsevier
The injection of safe doses of botulinum neurotoxin A (BoNT/A) have been reported to be
useful for the treatment of neuropathic pain, but it is still unknown how functional recovery is …

Botulinum neurotoxin application to the severed femoral nerve modulates spinal synaptic responses to axotomy and enhances motor recovery in rats

M Irintchev, O Guntinas-Lichius, A Irintchev - Neural Plasticity, 2018 - Wiley Online Library
Botulinum neurotoxin A (BoNT) and brain‐derived neurotrophic factor (BDNF) are known for
their ability to influence synaptic inputs to neurons. Here, we tested if these drugs can …

Botulinum toxin: from spasticity reliever to a neuromotor re-learning tool

RV Krishnan - International journal of neuroscience, 2005 - Taylor & Francis
Botulinum toxin is becoming increasingly popular as the drug of choice for relief of spasticity
in a wide range of conditions, from stroke to strabismus to vaginismus. Besides this role as …

Molecular mechanisms of treadmill therapy on neuromuscular atrophy induced via botulinum toxin A

SW Tsai, HL Chen, YC Chang, CM Chen - Neural Plasticity, 2013 - Wiley Online Library
Botulinum toxin A (BoNT‐A) is a bacterial zinc‐dependent endopeptidase that acts
specifically on neuromuscular junctions. BoNT‐A blocks the release of acetylcholine …

[HTML][HTML] Comparison of the Effects of Botulinum Toxin Doses on Nerve Regeneration in Rats with Experimentally Induced Sciatic Nerve Injury

S Hwang, M Seo, TH Lee, HJ Lee, J Park, BS Kwon… - Toxins, 2023 - mdpi.com
This study was designed to compare the effects of various doses of botulinum neurotoxin A
(BoNT/A) on nerve regeneration. Sixty-five six-week-old rats with sciatic nerve injury were …

Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons

JA Coffield, X Yan - Journal of Pharmacology and Experimental …, 2009 - ASPET
Botulinum neurotoxins (BoNTs) are extremely potent neuromuscular poisons that act
through soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) …

Reductions in motoneuronal neurofilament synthesis by successive axotomies: a possible explanation for the conditioning lesion effect on axon regeneration

W Tetzlaff, C Leonard, CA Krekoski, IM Parhad… - Experimental …, 1996 - Elsevier
Axons regenerate more rapidly after a test lesion if they received a conditioning lesion.
Previous work suggests that the cell body reaction to injury is responsible for this …

[HTML][HTML] Preclinical evidence for the role of botulinum neurotoxin A (BoNT/A) in the treatment of peripheral nerve injury

M Adler, S Pellett, SK Sharma, FJ Lebeda, ZF Dembek… - microorganisms, 2022 - mdpi.com
Traumatic peripheral nerve injuries tend to be more common in younger, working age
populations and can lead to long-lasting disability. Peripheral nerves have an impressive …

[HTML][HTML] Xeomin®, a Commercial Formulation of Botulinum Neurotoxin Type A, Promotes Regeneration in a Preclinical Model of Spinal Cord Injury

V Mastrorilli, F De Angelis, V Vacca, F Pavone… - Toxins, 2023 - mdpi.com
Xeomin® is a commercial formulation of botulinum neurotoxin type A (BoNT/A) clinically
authorized for treating neurological disorders, such as blepharospasm, cervical dystonia …