A number of signal transduction pathways are activated during Acute Kidney Injury (AKI). Of
particular interest is the Salt Inducible Kinase (SIK) signaling network, and its effects on the …

Despite optimal medical therapy, many patients with diabetic kidney disease (DKD)
progress to end-stage renal disease. The identification of new biomarkers and drug targets …

Salt-inducible kinase (SIK), which belongs to the sucrose non-fermenting 1/AMP-activated
protein kinase family, was first discovered in the adrenal cortex of a rat on a high-salt diet. As …

Background Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a
risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one …

The salt-inducible kinases (SIKs) 1 to 3, belonging to the AMPK-related kinase family, serve
as master regulators orchestrating a diverse set of physiological processes such as …

Salt-inducible kinases (SIKs) represent a subfamily of AMPK family kinases. SIK1 has been
shown to act as a mediator during the cellular adaptation to variations in intracellular sodium …

Salt-inducible kinases (SIKs) are promising therapeutic targets for modulating cytokine
responses during innate immune activation. The study of SIK inhibition in animal models of …

Introduction: The salt-inducible kinases originally cloned in adrenal glands of high salt diet-
fed rats, generally named as SIKs, are highly evolutionarily conserved serine/threonine …

Salt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑
activated protein kinase family. They are expressed ubiquitously in humans. Under normal …

Salt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP-
activated protein kinase family. They are expressed ubiquitously in humans. Under normal …