Increasing evidence suggests that abnormal synaptic function leads to neuronal
developmental disorders and is an important component of the etiology of autism spectrum …

Autism is a brain developmental disorder characterized by impaired social interaction and
communication, as well as restricted and repetitive behaviors. The neurexin-1 (NRXN1) …

Neurexins are presynaptic membrane cell-adhesion molecules which bind to neuroligins, a
family of proteins that are associated with autism. To explore the possibility that structural …

Neuroligins are postsynaptic membrane cell-adhesion molecules which bind to β-neurexins,
a family of proteins that act as neuronal cell surface receptors. To explore the possibility that …

Autism is a neurodevelopmental disorder of complex etiology in which genetic factors play a
major role. We have implicated the neurexin 1 (NRXN1) gene in two independent subjects …

Aim: Neurexin 1 has two major protein isoforms using alternative promoters, coding for the
alpha-neurexin 1 (α-NRXN1) and beta-neurexin 1 (β-NRXN1) genes. This study is to …

Over the past 3 decades, the prevalence of autism spectrum disorder (ASD) has increased
globally from 20 to 28 million cases making ASD the fastest-growing developmental …

The three members of the human neurexin gene family, neurexin 1 (NRXN1), neurexin 2
(NRXN2), and neurexin 3 (NRXN3), encode neuronal adhesion proteins that have important …

Autism is a common and frequently disabling neurodevelopmental disorder with a strong
genetic basis. Human genetic studies have discovered mutations disrupting exons of the …

Members of the neurexin gene family, neurexin 1 (NRXN1), neurexin 2 (NRXN2), and
neurexin 3 (NRXN3) encode important components of synaptic function implicated in autism …