Fundamental metabolic pathways are essential for mammalian cells to provide energy,
precursors for biosynthesis of macromolecules, and reducing power for redox regulation …

Immune cells survey and patrol throughout the body and sometimes take residence in niche
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …

Cancer cells employ glycolysis for their survival and growth (the “Warburg effect”).
Consequently, surrounding cells including immune cells in the tumor microenvironment …

Cellular energy metabolism not only promotes tumor cell growth and metastasis but also
directs immune cell survival, proliferation and the ability to perform specific and functional …

Cancer is a complex succession of disease progressively associated with uncontrolled
growth and capability of cells eluding the body's natural mechanism of defense and cell …

Metabolic disorders and abnormal immune function changes occur in tumor tissues and
cells to varying degrees. There is increasing evidence that reprogrammed energy …

Immune cells are one of the most versatile cell types, as they can tailor their metabolic
activity according to their required function. In response to diverse environmental cues …

Highlights•Memory T cells have quiescent metabolism.•Activation of T cells triggers both
glycolysis and oxidative phosphorylation.•Elevated T cell metabolic activity is necessary at …

T cells play critical roles in host defenses against cancer. External signals prompt activation
of naïve T cells, triggering modulation of their immune functions. Emerging evidence reveals …

The tumor microenvironment (TME) has become a major research focus in recent years. The
TME differs from the normal extracellular environment in parameters such as nutrient supply …