Human infection with Cryptococcus neoformans, a common fungal pathogen, follows
deposition of yeast spores in the lung alveoli. The subsequent host–pathogen interaction …

To produce chronic infection, microbial pathogens must escape host immune defenses.
Infection with the human pathogenic fungus Cryptococcus neoformans is typically chronic …

We investigated the outcome of the interaction of Cryptococcus neoformans with murine
macrophages using laser scanning cytometry (LSC). Previous results in our lab had shown …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

Background Cryptococcus neoformans is an encapsulated yeast that is a facultative
intracellular pathogen. The interaction between macrophages and C. neoformans is critical …

Cryptococcus neoformans is a leading cause of invasive fungal infections among
immunocompromised patients. However, the cellular constituents of the innate immune …

The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is
considerable evidence that this microbe can damage host cells and tissues. In this essay …

Recently, we demonstrated that human monocyte-derived macrophages (MDM) treated with
chloroquine or ammonium chloride had markedly increased antifungal activity against the …

After inhalation of infectious particles, Cryptococcus neoformans resides in the alveolar
spaces, where it can survive and replicate in the extracellular environment. This yeast has …