In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system.

GJ Nuovo, F Gallery, P MacConnell… - The American journal of …, 1994 - ncbi.nlm.nih.gov
This study determined the distribution of in situ polymerase chain reaction (PCR)-amplified
HIV-1 nucleic acids in the central nervous system (CNS). Amplified viral DNA was detected …

Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients

E Sinclair, F Gray, A Ciardi… - Journal of Neuropathology …, 1994 - academic.oup.com
The stage of HIV infection at which the virus enters the nervous system remains poorly
understood. Examination of brains of HIV-positive non-AIDS patients often shows …

Localization of HIV‐1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry

K Takahashi, SL Wesselingh, DE Griffin… - Annals of …, 1996 - Wiley Online Library
Human immunodeficiency virus type 1 (HIV‐1) infects the brains of a majority of patients with
the acquired immunodeficiency syndrome (AIDS), and has been linked to the development …

Human Immunodeficiency Virus (HIV) Distribution in HIV Encephalitis: Study of 19 Cases with Combined Use of In Situ Hybridization and Immunocytochemistry

G Gosztonyi, J Artigas, L Lamperth… - … of Neuropathology & …, 1994 - academic.oup.com
Brains of 19 AIDS patients with HIV encephalitis were examined by immunohistochemistry
and in situ hybridization using antisense HIV DNA and RNA probes. Double …

Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/in situ hybridisation technique

SF An, M Groves, B Giometto, AAJ Beckett… - Acta …, 1999 - Springer
In the brain of patients with AIDS, HIV-1 is localised in a productive form in mononuclear
cells. One issue that still needs clarification is whether HIV is localised in cells other than …

Low levels of human immunodeficiency virus replication in the brain tissue of children with severe acquired immunodeficiency syndrome encephalopathy.

R Vazeux, C Lacroix-Ciaudo, S Blanche… - The American journal …, 1992 - ncbi.nlm.nih.gov
The authors examined the autopsy brain samples of nine children infected with human
immunodeficiency virus (HIV) at birth by histology, immunologic staining, and in situ …

[HTML][HTML] Brain cell reservoirs of latent virus in presymptomatic HIV-infected individuals

KA Thompson, CL Cherry, JE Bell… - The American journal of …, 2011 - Elsevier
We detected HIV-1 DNA in pure populations of perivascular macrophages, parenchymal
microglia, and astrocytes, isolated using laser microdissection from brain tissue of five …

[HTML][HTML] Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain …

SL Wesselingh, K Takahashi, JD Glass… - Journal of …, 1997 - Elsevier
HIV-induced neurological disease is postulated to be caused by indirect mechanisms.
Tumor necrosis factor (TNF) α is increased in the brains in human immunodeficiency virus …

Detection of HIV-1 gene sequences in hippocampal neurons isolated from postmortem AIDS brains by laser capture microdissection

J Torres-Muñoz, P Stockton, N Tacoronte… - … of Neuropathology & …, 2001 - academic.oup.com
We employed laser capture microdissection to remove individual pyramidal neurons from
the CA1, CA3, and CA4 regions of formalin-fixed, paraffin-embedded hippocampus from 8 …

Human immunodeficiency virus type 1 is present in the cerebrospinal fluid of a majority of infected individuals

F Chiodi, B Keys, J Albert, L Hagberg… - Journal of clinical …, 1992 - Am Soc Microbiol
Cerebrospinal fluid (CSF) specimens from 63 patients with different severities of human
immunodeficiency virus (HIV-1) infection, including asymptomatic virus carriers, were …