Severe acute renal failure (ARF) remains a common, largely treatment-resistant clinical
problem with disturbingly high mortality rates. Therefore, we tested whether administration of …

Introduction Studies have shown that stem cells exert their therapeutic effects on acute
kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in …

Background: Although renal tubular epithelium has a great capacity for repair it has been
suggested that the administration of mesenchymal stem cells may accelerate the recovery …

Acute kidney injury (AKI) is a major clinical problem in which a critical vascular,
pathophysiological component is recognized. We demonstrated previously that …

Mesenchymal stem cells are renoprotective in ischemia/reperfusion-induced acute renal
failure in rats. Background Adult stem cells are promising for the development of novel …

PURPOSE: The potential use of stem cells for acute and chronic renal injury is under
intensive investigation. We summarized the current literature on the potential therapeutic …

The most commonly used therapeutic targets in nephrology are the reduction of injury, the
delay of progression, or renal replacement therapy. Many animal and human studies …

BACKGROUND: Ischemia and reperfusion injury (I/R) is the major cause of acute renal
failure (ARF) with high mortality rates. Because alternative therapies are needed, we …

The potential role of mesenchymal stem cells (MSCs, also called mesenchymal stromal
cells) in endogenous repair and cell-based therapies for acute kidney injury (AKI) is under …

Acute kidney injury (AKI) is classically described as a rapid loss of kidney function. AKI
affects more than 15% of all hospital admissions and is associated with elevated mortality …